Potential drug targets for Neuromyelitis optica spectrum disorders (NMOSD): A Mendelian randomization analysis

Hongqi Meng; Shengnan Wang; Lulu Gu; Yuhao Wang; Beibei Li; Ruyue Lv; Letian Xue; Yanming Ren; Li Xu; Ling Mao; Peng Sun

doi:10.1371/journal.pone.0322098

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Open Access

Peer-reviewed

Research Article

Potential drug targets for Neuromyelitis optica spectrum disorders (NMOSD): A Mendelian randomization analysis

Hongqi Meng ,

Contributed equally to this work with: Hongqi Meng, Shengnan Wang

Roles Conceptualization, Data curation, Resources, Validation, Writing – original draft

Affiliations Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei Province, China
⨯
Shengnan Wang ,

Contributed equally to this work with: Hongqi Meng, Shengnan Wang

Roles Data curation, Methodology, Resources, Validation, Writing – original draft

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Lulu Gu,

Roles Conceptualization, Software

Affiliations Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei Province, China
⨯
Yuhao Wang,

Roles Formal analysis, Supervision

Affiliations Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei Province, China
⨯
Beibei Li,

Roles Investigation, Software, Supervision

Affiliations Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei Province, China
⨯
Ruyue Lv,

Roles Resources, Supervision

Affiliations Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei Province, China
⨯
Letian Xue,

Roles Validation, Visualization

Affiliations Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei Province, China
⨯
Yanming Ren,

Roles Formal analysis, Investigation

Affiliations Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei Province, China
⨯
Li Xu,

Roles Formal analysis, Resources, Visualization

Affiliations Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei Province, China
⨯
Ling Mao ,

Roles Data curation, Formal analysis, Writing – review & editing

* E-mail: maoling@hust.edu.cn (LM); 1031737523@qq.com (PS)

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Peng Sun

Roles Funding acquisition, Resources, Writing – review & editing

* E-mail: maoling@hust.edu.cn (LM); 1031737523@qq.com (PS)

Affiliations Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei Province, China

https://orcid.org/0000-0001-9576-6102

⨯

Potential drug targets for Neuromyelitis optica spectrum disorders (NMOSD): A Mendelian randomization analysis

Hongqi Meng,
Shengnan Wang,
Lulu Gu,
Yuhao Wang,
Beibei Li,
Ruyue Lv,
Letian Xue,
Yanming Ren,
Li Xu,
Ling Mao

Published: April 28, 2025
https://doi.org/10.1371/journal.pone.0322098

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