5-O-Methylvisammioside inhibits HMGB1-induced Angiogenesis of hepatocellular carcinoma through RAGE/MEK/ERK signaling pathway

Wenyue Hou; Ting Zou; Yichao Yan; Yaolong Zhuang; Shaomei Gao; Huijun Ju; Fei Yao; Qin Yuan; Liang Zhou; Guoqiang Liang; Xiudao Song; Lurong Zhang

doi:10.1371/journal.pone.0322056

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Open Access

Peer-reviewed

Research Article

5-O-Methylvisammioside inhibits HMGB1-induced Angiogenesis of hepatocellular carcinoma through RAGE/MEK/ERK signaling pathway

Wenyue Hou ,

Contributed equally to this work with: Wenyue Hou, Ting Zou

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China
⨯
Ting Zou ,

Contributed equally to this work with: Wenyue Hou, Ting Zou

Roles Formal analysis, Funding acquisition, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China
⨯
Yichao Yan,

Roles Formal analysis, Investigation, Methodology

Affiliation Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China
⨯
Yaolong Zhuang,

Roles Investigation, Validation

Affiliations Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China, College of Life Sciences, Xuzhou Medical University, Xuzhou, China
⨯
Shaomei Gao,

Roles Investigation, Visualization

Affiliation Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China
⨯
Huijun Ju,

Roles Investigation, Validation

Affiliation Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China
⨯
Fei Yao,

Roles Resources, Supervision

Affiliations Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China, Suzhou Academy of Wu Men Chinese Medicine, Suzhou, China
⨯
Qin Yuan,

Roles Data curation

Affiliations Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China, Suzhou Academy of Wu Men Chinese Medicine, Suzhou, China
⨯
Liang Zhou,

Roles Resources, Supervision

Affiliations Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China, Suzhou Academy of Wu Men Chinese Medicine, Suzhou, China
⨯
Guoqiang Liang,

Roles Resources

Affiliations Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China, Suzhou Academy of Wu Men Chinese Medicine, Suzhou, China
⨯
Xiudao Song,

Roles Writing – original draft, Writing – review & editing

Affiliations Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China, Suzhou Academy of Wu Men Chinese Medicine, Suzhou, China
⨯
Lurong Zhang

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: fsyy00571@njucm.edu.cn

Affiliations Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China, Suzhou Academy of Wu Men Chinese Medicine, Suzhou, China

https://orcid.org/0009-0003-2905-7051

⨯

5-O-Methylvisammioside inhibits HMGB1-induced Angiogenesis of hepatocellular carcinoma through RAGE/MEK/ERK signaling pathway

Wenyue Hou,
Ting Zou,
Yichao Yan,
Yaolong Zhuang,
Shaomei Gao,
Huijun Ju,
Fei Yao,
Qin Yuan,
Liang Zhou,
Guoqiang Liang

Published: May 5, 2025
https://doi.org/10.1371/journal.pone.0322056

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Hepatocellular carcinoma
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Angiogenesis
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Endothelial cells
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Signal inhibition
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ERK signaling cascade
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Tumor angiogenesis
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