scFv intrabody targeting wildtype TDP-43 presents protective effects in a cellular model of TDP-43 proteinopathy

• Yara Al Ojaimi ,

  Contributed equally to this work with: Yara Al Ojaimi, Rudolf Hergesheimer

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  * E-mail: yara.alojaimi@univ-tours.fr

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  https://orcid.org/0000-0002-5270-155X

  ⨯
• Rudolf Hergesheimer ,

  Contributed equally to this work with: Yara Al Ojaimi, Rudolf Hergesheimer

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  ⨯
• Anna A. Chami,

  Roles Investigation

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  ⨯
• Hugo Alarcan,

  Roles Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  ⨯
• Johanna Augros,

  Roles Investigation

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  https://orcid.org/0009-0009-5005-0819

  ⨯
• Audrey Dangoumau,

  Roles Writing – review & editing

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  ⨯
• Shanez Haouari,

  Roles Investigation

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  ⨯
• Jérôme Bourgeais,

  Roles Investigation

  Affiliation INSERM UMR1069 N2COx, Tours University, Tours, France

  ⨯
• Antoine Lefevre,

  Roles Investigation

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  ⨯
• Samira Osman,

  Roles Writing – review & editing

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  https://orcid.org/0009-0002-0105-621X

  ⨯
• Patrick Emond,

  Roles Writing – review & editing

  Affiliations Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France, CHU de Tours, Service de Médecine Nucléaire In Vitro, Tours, France

  ⨯
• Patrick Vourc’h,

  Roles Writing – review & editing

  Affiliations Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France, CHU de Tours, Service de Biochimie et Biologie Moléculaire, Tours, France

  ⨯
• Christian R. Andres,

  Roles Writing – review & editing

  Affiliations Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France, CHU de Tours, Service de Biochimie et Biologie Moléculaire, Tours, France

  ⨯
• Philippe Corcia,

  Roles Writing – review & editing

  Affiliations Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France, CHU de Tours, Service de Neurologie, Tours, France

  ⨯
• Olivier Herault,

  Roles Writing – review & editing

  Affiliation INSERM UMR1069 N2COx, Tours University, Tours, France

  ⨯
• Pierre Martineau,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation IRCM, Univ Montpellier, Inserm, ICM, Montpellier, France.

  https://orcid.org/0000-0002-7993-7183

  ⨯
• Débora Lanznaster ,

  Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  ¶‡ DL and HB authors also contributed equally to this work.

  Affiliation Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France

  ⨯
•  [ ... ],
• Hélène Blasco

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  ¶‡ DL and HB authors also contributed equally to this work.

  Affiliations Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France, CHU de Tours, Service de Biochimie et Biologie Moléculaire, Tours, France

  https://orcid.org/0000-0001-6107-0035

  ⨯
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