Roscovitine enhances the bactericidal activity of the airway surface liquid of the cystic fibrosis bronchial epithelium but does not protect against Pseudomonas aeruginosa infection

Adrien Maupas; Anaëlle Muggeo; Pierre Vermeulen; Sophie Moussalih; Edouard Sage; Emilie Luczka-Majérus; Christelle Coraux; Thomas Guillard

doi:10.1371/journal.pone.0321996

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Open Access

Peer-reviewed

Research Article

Roscovitine enhances the bactericidal activity of the airway surface liquid of the cystic fibrosis bronchial epithelium but does not protect against Pseudomonas aeruginosa infection

Adrien Maupas,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Université de Reims Champagne-Ardenne, INSERM, P3Cell, U 1250, Reims, France
⨯
Anaëlle Muggeo,

Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

Affiliation Université de Reims Champagne-Ardenne, INSERM, CHU de Reims, Laboratoire de Bactériologie-Virologie-Hygiène Hospitalière, P3Cell, U 1250, Reims, France
⨯
Pierre Vermeulen,

Roles Formal analysis, Writing – review & editing

Affiliation Université de Reims Champagne-Ardenne, INSERM, P3Cell, U 1250, Reims, France
⨯
Sophie Moussalih,

Roles Formal analysis, Writing – review & editing

Affiliation Université de Reims Champagne-Ardenne, INSERM, P3Cell, U 1250, Reims, France
⨯
Edouard Sage,

Roles Formal analysis, Writing – review & editing

Affiliations Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France, Department of Thoracic Surgery and Lung Transplantation, Foch Hospital, Suresnes, France
⨯
Emilie Luczka-Majérus,

Roles Formal analysis, Writing – review & editing

Affiliation Université de Reims Champagne-Ardenne, INSERM, P3Cell, U 1250, Reims, France
⨯
Christelle Coraux,

Roles Conceptualization, Writing – review & editing

Affiliation Université de Reims Champagne-Ardenne, INSERM, P3Cell, U 1250, Reims, France
⨯
Thomas Guillard

Roles Data curation, Writing – original draft, Writing – review & editing

* E-mail: tguillard@chu-reims.fr

Affiliation Université de Reims Champagne-Ardenne, INSERM, CHU de Reims, Laboratoire de Bactériologie-Virologie-Hygiène Hospitalière, P3Cell, U 1250, Reims, France

https://orcid.org/0000-0002-3795-0398

⨯

Roscovitine enhances the bactericidal activity of the airway surface liquid of the cystic fibrosis bronchial epithelium but does not protect against Pseudomonas aeruginosa infection

Adrien Maupas,
Anaëlle Muggeo,
Pierre Vermeulen,
Sophie Moussalih,
Edouard Sage,
Emilie Luczka-Majérus,
Christelle Coraux,
Thomas Guillard

Published: May 5, 2025
https://doi.org/10.1371/journal.pone.0321996

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Pseudomonas aeruginosa
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Epithelium
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Cystic fibrosis
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Cell cultures
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MTT assay
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Pseudomonas infections
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Respiratory infections
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Toxicity
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