Curcumin ameliorates aging-induced blood-testis barrier disruption by regulating AMPK/mTOR mediated autophagy

Chen Xue; Zhenxing Yan; Wenjing Cheng; Dong Zhang; Rong Zhang; Hongwei Duan; Lihong Zhang; Xiaofei Ma; Junjie Hu; Jian Kang; Xiaojun Ma

doi:10.1371/journal.pone.0321752

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Open Access

Peer-reviewed

Research Article

Curcumin ameliorates aging-induced blood-testis barrier disruption by regulating AMPK/mTOR mediated autophagy

Chen Xue,

Roles Conceptualization, Formal analysis, Methodology, Software, Writing – original draft

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China
⨯
Zhenxing Yan,

Roles Formal analysis, Methodology, Software

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China
⨯
Wenjing Cheng,

Roles Formal analysis, Methodology, Software

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China
⨯
Dong Zhang,

Roles Formal analysis, Software

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China
⨯
Rong Zhang,

Roles Formal analysis

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China
⨯
Hongwei Duan,

Roles Writing – review & editing

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China
⨯
Lihong Zhang,

Roles Writing – review & editing

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China
⨯
Xiaofei Ma,

Roles Writing – review & editing

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China
⨯
Junjie Hu ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: hujj@gsau.edu.cn (JH); kj89260541@163.com (JK); maxj712@163.com (XM)

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China

https://orcid.org/0000-0003-2522-4724

⨯
Jian Kang ,

Roles Supervision, Writing – review & editing

* E-mail: hujj@gsau.edu.cn (JH); kj89260541@163.com (JK); maxj712@163.com (XM)

Affiliation School of Animal Science and technology, Guangdong polytechnic of science and trade, Guangzhou, Guangdong, China
⨯
Xiaojun Ma

Roles Supervision, Writing – review & editing

* E-mail: hujj@gsau.edu.cn (JH); kj89260541@163.com (JK); maxj712@163.com (XM)

Affiliations College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China, Key Laboratory of Animal Reproductive Physiology and Reproductive Regulation in Gansu Province, Lanzhou, Lanzhou, Gansu, China
⨯

Curcumin ameliorates aging-induced blood-testis barrier disruption by regulating AMPK/mTOR mediated autophagy

Chen Xue,
Zhenxing Yan,
Wenjing Cheng,
Dong Zhang,
Rong Zhang,
Hongwei Duan,
Lihong Zhang,
Xiaofei Ma,
Junjie Hu,
Jian Kang

Published: April 24, 2025
https://doi.org/10.1371/journal.pone.0321752

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