Predicting breast cancer prognosis based on a novel pathomics model through CHEK1 expression analysis using machine learning algorithms

Chen Chen; Dan Gao; Huan Yue; Huijing Wang; Rui Qu; Xiaochi Hu; Libo Luo

doi:10.1371/journal.pone.0321717

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Open Access

Peer-reviewed

Research Article

Predicting breast cancer prognosis based on a novel pathomics model through CHEK1 expression analysis using machine learning algorithms

Chen Chen,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft

Affiliation Breast and Thyroid Center, The First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China
⨯
Dan Gao,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization

Affiliation Breast and Thyroid Center, The First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China
⨯
Huan Yue,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization

Affiliation Clinical Laboratory, The First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China
⨯
Huijing Wang,

Roles Data curation, Formal analysis, Validation, Visualization

Affiliation Breast and Thyroid Center, The First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China
⨯
Rui Qu,

Roles Investigation, Methodology, Resources, Software, Validation, Visualization

Affiliation Breast and Thyroid Center, The First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China
⨯
Xiaochi Hu,

Roles Investigation, Methodology, Validation, Visualization

Affiliation Breast and Thyroid Center, The First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China
⨯
Libo Luo

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: luolb2012@126.com

Affiliation Breast and Thyroid Center, The First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China

https://orcid.org/0009-0008-7639-935X

⨯

Predicting breast cancer prognosis based on a novel pathomics model through CHEK1 expression analysis using machine learning algorithms

Chen Chen,
Dan Gao,
Huan Yue,
Huijing Wang,
Rui Qu,
Xiaochi Hu,
Libo Luo

Published: May 9, 2025
https://doi.org/10.1371/journal.pone.0321717

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Breast cancer
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Prognosis
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Gene expression
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Hepatocellular carcinoma
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Machine learning algorithms
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