CD38-targeted attenuated interferon alpha immunocytokine activates both innate and adaptive immune cells to drive anti-tumor activity

James F. Sampson; Hong Zhang; Dongmei Zhang; Mingying Bi; Adam Hinthorne; Sakeena Syed; Yuhong Zhang; Nibedita Chattopadhyay; Sabrina Collins; Sarah Pogue; Pia Björck; Michael Curley

doi:10.1371/journal.pone.0321622

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Open Access

Peer-reviewed

Research Article

CD38-targeted attenuated interferon alpha immunocytokine activates both innate and adaptive immune cells to drive anti-tumor activity

James F. Sampson,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Writing – original draft

Affiliation Oncology Drug Discovery Unit, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, United States of America

https://orcid.org/0000-0001-6741-7386

⨯
Hong Zhang,

Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Oncology Drug Discovery Unit, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, United States of America
⨯
Dongmei Zhang,

Roles Data curation, Investigation, Validation, Writing – review & editing

Affiliation Oncology Drug Discovery Unit, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, United States of America
⨯
Mingying Bi,

Roles Investigation

Affiliation Discovery R and D, Teva Pharmaceutical Industries, Ltd., Redwood City, United States of America
⨯
Adam Hinthorne,

Roles Data curation, Investigation, Methodology, Project administration, Resources

Affiliation Oncology Drug Discovery Unit, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, United States of America
⨯
Sakeena Syed,

Roles Data curation, Investigation, Methodology, Project administration, Resources

Affiliation Oncology Drug Discovery Unit, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, United States of America
⨯
Yuhong Zhang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Oncology Drug Discovery Unit, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, United States of America
⨯
Nibedita Chattopadhyay,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Oncology Drug Discovery Unit, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, United States of America
⨯
Sabrina Collins,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Oncology Drug Discovery Unit, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, United States of America
⨯
Sarah Pogue,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Discovery R and D, Teva Pharmaceutical Industries, Ltd., Redwood City, United States of America
⨯
Pia Björck,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Discovery R and D, Teva Pharmaceutical Industries, Ltd., Redwood City, United States of America
⨯
Michael Curley

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: michael.curley@takeda.com

Affiliation Oncology Drug Discovery Unit, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, United States of America

https://orcid.org/0009-0003-6621-4327

⨯

CD38-targeted attenuated interferon alpha immunocytokine activates both innate and adaptive immune cells to drive anti-tumor activity

James F. Sampson,
Hong Zhang,
Dongmei Zhang,
Mingying Bi,
Adam Hinthorne,
Sakeena Syed,
Yuhong Zhang,
Nibedita Chattopadhyay,
Sabrina Collins,
Sarah Pogue

Published: May 2, 2025
https://doi.org/10.1371/journal.pone.0321622

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