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Open Access
Peer-reviewed
Research Article
mTOR inhibition impacts the flagellin-augmented inflammatory and antimicrobial response of human airway epithelial cells to Pseudomonas aeruginosa
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Christine C.A. van Linge ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft
* E-mail: c.c.vanlinge@amsterdamumc.nl
Affiliations Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands
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Katina D. Hulme,
Roles Investigation, Methodology, Resources, Writing – review & editing
Affiliation Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Hessel Peters-Sengers,
Roles Formal analysis, Methodology, Software, Visualization, Writing – review & editing
Affiliations Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands
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Robert F.J. Kullberg,
Roles Investigation, Methodology, Writing – review & editing
Affiliations Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands
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Menno D. de Jong,
Roles Resources, Writing – review & editing
Affiliation Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Colin A. Russell,
Roles Resources, Writing – review & editing
Affiliations Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Global Health, School of Public Health, Boston University, Boston, Massachusetts, United States of America
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Alex F. de Vos,
Roles Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing – review & editing
Affiliations Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands
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Tom van der Poll
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – review & editing
Affiliations Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands, Division of Infectious Diseases, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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mTOR inhibition impacts the flagellin-augmented inflammatory and antimicrobial response of human airway epithelial cells to Pseudomonas aeruginosa
- Christine C.A. van Linge,
- Katina D. Hulme,
- Hessel Peters-Sengers,
- Robert F.J. Kullberg,
- Menno D. de Jong,
- Colin A. Russell,
- Alex F. de Vos,
- Tom van der Poll
- Published: May 8, 2025
- https://doi.org/10.1371/journal.pone.0321462