In vivo anti-ulceration effect of Pancratium maritimum extract against ethanol-induced rats via NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-κβ signaling pathways and its extract metabolite profile

• Rehab F. Taher ,

  Contributed equally to this work with: Rehab F. Taher, Eman M. Abd El ghany, Zeinab A. El-Gendy

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Natural Compounds Chemistry, National Research Centre, Dokki, Giza, Egypt

  ⨯
• Eman M. Abd El ghany ,

  Contributed equally to this work with: Rehab F. Taher, Eman M. Abd El ghany, Zeinab A. El-Gendy

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

  ⨯
• Zeinab A. El-Gendy ,

  Contributed equally to this work with: Rehab F. Taher, Eman M. Abd El ghany, Zeinab A. El-Gendy

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt

  ⨯
• Mai M. Elghonemy,

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Department of Natural Compounds Chemistry, National Research Centre, Dokki, Giza, Egypt

  ⨯
• Heba A. Hassan,

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Therapeutic Chemistry Department, National Research Centre, Dokki, Giza, Egypt

  ⨯
• Gehad A. Abdel Jaleel,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt

  ⨯
• Azza Hassan,

  Roles Methodology, Writing – original draft

  Affiliation Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt

  ⨯
• Tushar C. Sarker,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Texs A&M AgriLife Research Center, Overton, Texas, United States of America

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• Ahmed M. Abd-ElGawad ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  * E-mail: mohamed.farag@pharma.cu.edu.eg (MAF); aibrahim2@ksu.edu.sa (AMA-E); elshamynrc@yahoo.com (A.I.E.)

  Affiliation Plant Production Department, College of Food & Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia

  https://orcid.org/0000-0002-5903-6329

  ⨯
• Mohamed A. Farag ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: mohamed.farag@pharma.cu.edu.eg (MAF); aibrahim2@ksu.edu.sa (AMA-E); elshamynrc@yahoo.com (A.I.E.)

  Affiliations Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt, Healthcare Department, Saxony Egypt University (SEU), Badr City, Egypt

  ⨯
• Abdelsamed I. Elshamy

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  * E-mail: mohamed.farag@pharma.cu.edu.eg (MAF); aibrahim2@ksu.edu.sa (AMA-E); elshamynrc@yahoo.com (A.I.E.)

  Affiliation Department of Natural Compounds Chemistry, National Research Centre, Dokki, Giza, Egypt

  https://orcid.org/0000-0003-3302-3623

  ⨯