Quercetin alleviates cerebral ischemia and reperfusion injury in hyperglycemic animals by reducing endoplasmic reticulum stress through activating SIRT1

Jing Yang; Yan-Mei Ma; Lan Yang; Peng Li; Li Jing; P. Andy Li; Jian-Zhong Zhang

doi:10.1371/journal.pone.0321006

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Open Access

Peer-reviewed

Research Article

Quercetin alleviates cerebral ischemia and reperfusion injury in hyperglycemic animals by reducing endoplasmic reticulum stress through activating SIRT1

Jing Yang,

Roles Data curation, Investigation, Software, Writing – original draft

Affiliations NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China, Department of Dermatology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

https://orcid.org/0009-0004-7774-6123

⨯
Yan-Mei Ma,

Roles Formal analysis, Investigation

Affiliation NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China
⨯
Lan Yang,

Roles Funding acquisition, Investigation

Affiliation NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China
⨯
Peng Li,

Roles Investigation

Affiliation NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China
⨯
Li Jing,

Roles Conceptualization, Writing – review & editing

Affiliation NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China
⨯
P. Andy Li ,

Roles Conceptualization, Writing – review & editing

* E-mail: zhangjz@nxmu.edu.cn (JZZ); pli@nccu.edu (PAL)

Affiliation Department of Pharmaceutical Sciences, Biomanufacturing Research Institute Technology Enterprise, College of Health and Sciences, North Carolina Central University, Durham, North Carolina, United States of America

https://orcid.org/0000-0002-8712-3147

⨯
Jian-Zhong Zhang

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: zhangjz@nxmu.edu.cn (JZZ); pli@nccu.edu (PAL)

Affiliation NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China
⨯

Quercetin alleviates cerebral ischemia and reperfusion injury in hyperglycemic animals by reducing endoplasmic reticulum stress through activating SIRT1

Jing Yang,
Yan-Mei Ma,
Lan Yang,
Peng Li,
Li Jing,
P. Andy Li,
Jian-Zhong Zhang

Published: April 24, 2025
https://doi.org/10.1371/journal.pone.0321006

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Apoptosis
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Endoplasmic reticulum
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