Identification of biomarkers associated with inflammatory response in Parkinson’s disease by bioinformatics and machine learning

Yatan Li; Wei Jia; Chen Chen; Cheng Chen; Jinchao Chen; Xinling Yang; Pei Liu

doi:10.1371/journal.pone.0320257

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Open Access

Peer-reviewed

Research Article

Identification of biomarkers associated with inflammatory response in Parkinson’s disease by bioinformatics and machine learning

Yatan Li ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

¶☯ These authors contributed equally to this work and should be considered co-first authors.

Affiliation Department of Pharmacy, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi, China
⨯
Wei Jia ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

¶☯ These authors contributed equally to this work and should be considered co-first authors.

Affiliation The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China
⨯
Chen Chen,

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliation College of Information Science and Engineering, Xinjiang University, Urumqi, China
⨯
Cheng Chen,

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliation College of Software, Xinjiang University, Urumqi, China
⨯
Jinchao Chen,

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliation College of Information Science and Engineering, Xinjiang University, Urumqi, China
⨯
Xinling Yang ,

Roles Conceptualization, Data curation, Formal analysis, Investigation

* E-mail: yangxinling2014@163.com (XY); lp374187120@163.com (PL)

Affiliations Xinjiang Key Laboratory of Neurology, Urumqi, China, Xinjiang Medical University, Urumqi, China
⨯
Pei Liu

Roles Conceptualization, Data curation, Formal analysis, Investigation

* E-mail: yangxinling2014@163.com (XY); lp374187120@163.com (PL)

Affiliation College of Information Science and Engineering, Xinjiang University, Urumqi, China

https://orcid.org/0009-0002-4130-7941

⨯

Identification of biomarkers associated with inflammatory response in Parkinson’s disease by bioinformatics and machine learning

Yatan Li,
Wei Jia,
Chen Chen,
Cheng Chen,
Jinchao Chen,
Xinling Yang,
Pei Liu

Published: May 28, 2025
https://doi.org/10.1371/journal.pone.0320257

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Biomarkers
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Parkinson disease
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Gene expression
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Genetic screens
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Inflammation
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Machine learning algorithms
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MicroRNAs
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