Intermittent hypoxic stimulation promotes efficient expression of Hypoxia-inducible factor-1α and exerts a chondroprotective effect in an animal osteoarthritis model

• Ryota Cha ,

  Contributed equally to this work with: Ryota Cha, Shuji Nakagawa, Tsunao Kishida

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯
• Shuji Nakagawa ,

  Contributed equally to this work with: Ryota Cha, Shuji Nakagawa, Tsunao Kishida

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliation Department of Sports and Para-Sports Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯
• Yuji Arai ,

  Roles Funding acquisition, Project administration, Validation, Writing – review & editing

  * E-mail: y123arai@koto.kpu-m.ac.jp

  ¶‡ YA, AI, NO,YF,KK, KN and OM, KT also contributed equally to this work.

  Affiliation Department of Sports and Para-Sports Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  https://orcid.org/0000-0003-0784-7426

  ⨯
• Atsuo Inoue ,

  Roles Data curation, Funding acquisition, Methodology

  ¶‡ YA, AI, NO,YF,KK, KN and OM, KT also contributed equally to this work.

  Affiliation Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯
• Naoki Okubo ,

  Roles Validation

  ¶‡ YA, AI, NO,YF,KK, KN and OM, KT also contributed equally to this work.

  Affiliation Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯
• Yuta Fujii ,

  Roles Investigation, Resources

  ¶‡ YA, AI, NO,YF,KK, KN and OM, KT also contributed equally to this work.

  Affiliation Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯
• Kenta Kaihara ,

  Roles Conceptualization, Software

  ¶‡ YA, AI, NO,YF,KK, KN and OM, KT also contributed equally to this work.

  Affiliation Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯
• Kei Nakamura ,

  Roles Formal analysis

  ¶‡ YA, AI, NO,YF,KK, KN and OM, KT also contributed equally to this work.

  Affiliation Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯
• Tsunao Kishida ,

  Contributed equally to this work with: Ryota Cha, Shuji Nakagawa, Tsunao Kishida

  Roles Methodology

  Affiliation Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯
• Osam Mazda ,

  Roles Supervision

  ¶‡ YA, AI, NO,YF,KK, KN and OM, KT also contributed equally to this work.

  Affiliation Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯
• Kenji Takahashi

  Roles Funding acquisition, Supervision, Validation

  ¶‡ YA, AI, NO,YF,KK, KN and OM, KT also contributed equally to this work.

  Affiliation Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

  ⨯