Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations

Nakesha Agyapong; Leslie Dominguez-Ortega; Brian Macdonough; Patrick Mulluso; Sagar Patel; Briti Prajapati; Brian Saville; Andrew Shapiro; Ethan Trim; Kara Battaglia; Jocelyn Herrera; Gianna Garifo-MacPartland; Dianne Newcomb; Latoya Okundaye; Heather Paglia; Julia Paxson

doi:10.1371/journal.pone.0319723

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Peer-reviewed

Research Article

Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations

Nakesha Agyapong ,

Contributed equally to this work with: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Leslie Dominguez-Ortega ,

Contributed equally to this work with: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Brian Macdonough ,

Contributed equally to this work with: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Patrick Mulluso ,

Contributed equally to this work with: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Sagar Patel ,

Contributed equally to this work with: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Briti Prajapati ,

Contributed equally to this work with: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Brian Saville ,

Contributed equally to this work with: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America

https://orcid.org/0009-0003-1722-4035

⨯
Andrew Shapiro ,

Contributed equally to this work with: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America

https://orcid.org/0009-0007-6878-6774

⨯
Ethan Trim ,

Contributed equally to this work with: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Kara Battaglia,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Jocelyn Herrera,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Gianna Garifo-MacPartland,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Dianne Newcomb,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Latoya Okundaye,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
Heather Paglia,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America
⨯
[ ... ],
Julia Paxson

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: jpaxson@holycross.edu

Affiliation College of the Holy Cross, Worcester, Massachusetts, United States of America

https://orcid.org/0009-0008-9183-4225

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Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations

Nakesha Agyapong,
Leslie Dominguez-Ortega,
Brian Macdonough,
Patrick Mulluso,
Sagar Patel,
Briti Prajapati,
Brian Saville,
Andrew Shapiro,
Ethan Trim,
Kara Battaglia

Published: July 23, 2025
https://doi.org/10.1371/journal.pone.0319723

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