Verification of emerging genomic mutations in Mycobacterium tuberculosis allows transmission chains to be distinguished in an epidemiological typing cluster extending over thirty years

• Rina de Zwaan ,

  Contributed equally to this work with: Rina de Zwaan, Gerard de Vries

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

  ⨯
• Gerard de Vries ,

  Contributed equally to this work with: Rina de Zwaan, Gerard de Vries

  Roles Conceptualization, Data curation, Methodology, Writing – review & editing

  Affiliation Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

  ⨯
• Ella Ubbelohde,

  Roles Data curation

  Affiliations Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, KNCV Tuberculosis Foundation, The Hague, The Netherlands

  ⨯
• Arnout Mulder,

  Roles Data curation, Software

  Affiliation Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

  ⨯
• Miranda Kamst-van Agterveld,

  Roles Project administration, Supervision

  Affiliation Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

  ⨯
• Karin Rebel,

  Roles Data curation

  Affiliation TB Department, Municipal Public Health Services (GGD), Utrecht, The Netherlands

  ⨯
• Saskia Kautz,

  Roles Conceptualization

  Affiliation TB Department, Municipal Public Health Services (GGD), Rotterdam, The Netherlands

  ⨯
• Kristin Kremer,

  Roles Formal analysis, Project administration, Supervision, Writing – review & editing

  Affiliation KNCV Tuberculosis Foundation, The Hague, The Netherlands

  ⨯
• Richard M. Anthony ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: richard.anthony@rivm.nl

  ¶‡ RMA and DVS also contributed equally to this work.

  Affiliation Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

  https://orcid.org/0000-0002-0550-5273

  ⨯
• Dick van Soolingen

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

  ¶‡ RMA and DVS also contributed equally to this work.

  Affiliation Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

  ⨯