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Open Access
Peer-reviewed
Research Article
Enhancement of YTHDF2 plays a protective role in acute IRI models through downregulation of TUG1 expression
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Hong-Fei He ,
Contributed equally to this work with: Hong-Fei He, Shuang Hou, Xiao-Ya Ma
Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft
Affiliations Department of hepatobiliary surgery, Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,, Center for Energy Metabolism and Reproduction, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen City, Guangdong Province, People’s Republic of China,, School of clinical medicine, Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,
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Shuang Hou ,
Contributed equally to this work with: Hong-Fei He, Shuang Hou, Xiao-Ya Ma
Roles Investigation, Visualization
Affiliation School of clinical medicine, Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,
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Xiao-Ya Ma ,
Contributed equally to this work with: Hong-Fei He, Shuang Hou, Xiao-Ya Ma
Roles Data curation, Writing – original draft
Affiliations Center for Energy Metabolism and Reproduction, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen City, Guangdong Province, People’s Republic of China,, Department of Cardiology, Shenzhen Guangming District People’s Hospital, Shenzhen City, Guangdong Province, People’s Republic of China,
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Song-song Huang ,
Roles Formal analysis, Visualization
¶‡ These authors contributed equally to this work.
Affiliation Department of Pathology, Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,
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Bo Yang ,
Roles Formal analysis, Resources, Visualization
¶‡ These authors contributed equally to this work.
Affiliations School of clinical medicine, Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,, Department of organ transplantation, Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,
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Jun-Kang Wang ,
Roles Formal analysis, Validation
¶‡ These authors contributed equally to this work.
Affiliations School of clinical medicine, Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,, Affiliated Hospital of Hangzhou Normal University, Hangzhou City, Zhejiang Province, People’s Republic of China,
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Yuan Xu ,
Roles Conceptualization, Funding acquisition, Methodology, Project administration
* E-mail: 793215044@qq.com (YX); lei.tan19800707@njmu.edu.cn (LT); lihaiyang@gmc.edu.cn (HYL)
Affiliations School of clinical medicine, Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,, Department of organ transplantation, Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,
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Lei Tan ,
Roles Project administration, Supervision, Validation, Writing – review & editing
* E-mail: 793215044@qq.com (YX); lei.tan19800707@njmu.edu.cn (LT); lihaiyang@gmc.edu.cn (HYL)
Affiliations Innovation Center of Suzhou Nanjing Medical University, Suzhou City, Jiangsu Province, People’s Republic of China,, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing City, Jiangsu Province, People’s Republic of China,, National Center of Technology Innovation for Biopharmaceuticals, Suzhou City, Jiangsu Province, People’s Republic of China
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Hai-Yang Li
Roles Funding acquisition, Project administration, Supervision, Validation
* E-mail: 793215044@qq.com (YX); lei.tan19800707@njmu.edu.cn (LT); lihaiyang@gmc.edu.cn (HYL)
Affiliations Department of hepatobiliary surgery, Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,, School of clinical medicine, Guizhou Medical University, Guiyang City, Guizhou Province, People’s Republic of China,
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Enhancement of YTHDF2 plays a protective role in acute IRI models through downregulation of TUG1 expression
- Hong-Fei He,
- Shuang Hou,
- Xiao-Ya Ma,
- Song-song Huang,
- Bo Yang,
- Jun-Kang Wang,
- Yuan Xu,
- Lei Tan,
- Hai-Yang Li
- Published: April 24, 2025
- https://doi.org/10.1371/journal.pone.0319605