Restoration of angiogenic capacity in senescent endothelial cells by a pharmacological reprogramming approach

Katrin Kalies; Kai Knöpp; Susanne Koch; Claudia Pilowski; Leonie Wurmbrand; Daniel Sedding

doi:10.1371/journal.pone.0319381

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Open Access

Peer-reviewed

Research Article

Restoration of angiogenic capacity in senescent endothelial cells by a pharmacological reprogramming approach

Katrin Kalies ,

Contributed equally to this work with: Katrin Kalies, Kai Knöpp

Roles Conceptualization, Formal analysis, Investigation, Project administration, Writing – original draft, Writing – review & editing

* E-mail: katrin.kalies@uk-halle.de (KK); kai.knoepp@ul-halle.de (KK)

Affiliation Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

https://orcid.org/0000-0003-3186-2167

⨯
Kai Knöpp ,

Contributed equally to this work with: Katrin Kalies, Kai Knöpp

Roles Conceptualization, Formal analysis, Investigation, Project administration, Writing – original draft, Writing – review & editing

* E-mail: katrin.kalies@uk-halle.de (KK); kai.knoepp@ul-halle.de (KK)

Affiliation Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
⨯
Susanne Koch,

Roles Investigation

Affiliation Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
⨯
Claudia Pilowski,

Roles Investigation

Affiliation Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
⨯
Leonie Wurmbrand,

Roles Investigation

Affiliation Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
⨯
Daniel Sedding

Roles Resources, Supervision, Writing – review & editing

Affiliation Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
⨯

Restoration of angiogenic capacity in senescent endothelial cells by a pharmacological reprogramming approach

Katrin Kalies,
Kai Knöpp,
Susanne Koch,
Claudia Pilowski,
Leonie Wurmbrand,
Daniel Sedding

Published: February 28, 2025
https://doi.org/10.1371/journal.pone.0319381

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Small interfering RNA
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