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Open Access
Peer-reviewed
Research Article
Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics
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Thomas E. Angel,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliation In vitro/In vivo Translation, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Zhuo Chen,
Roles Investigation
Affiliation In vitro/In vivo Translation, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Ahmed Moghieb,
Roles Investigation
Affiliation In vitro/In vivo Translation, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Sze-Ling Ng,
Roles Investigation, Supervision
Affiliation Respiratory and Immunology Research Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Allison M. Beal,
Roles Investigation, Supervision
Affiliation Respiratory and Immunology Research Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Carol Capriotti,
Roles Investigation
Affiliation Respiratory and Immunology Research Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Leonard Azzarano,
Roles Investigation
Affiliation In vitro/In vivo Translation, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Debra Comroe,
Roles Investigation
Affiliation In vitro/In vivo Translation, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Michael Adam,
Roles Investigation
Affiliation Oncology Extracellular Targeted Cancer Therapeutics, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Patrick Moore,
Roles Investigation
Affiliation Respiratory and Immunology Research Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Bao Hoang,
Roles Investigation
Affiliation In vitro/In vivo Translation, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Kelly Blough,
Roles Investigation
Affiliation In vitro/In vivo Translation, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Joanne Kuziw,
Roles Investigation
Affiliation In vitro/In vivo Translation, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Joshi M. Ramanjulu,
Roles Supervision
Affiliation Respiratory and Immunology Research Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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G. Scott Pesiridis
Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing
* E-mail: g.s.pesiridis@gsk.com
Affiliation Discovery Project Leadership Team, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
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Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics
- Thomas E. Angel,
- Zhuo Chen,
- Ahmed Moghieb,
- Sze-Ling Ng,
- Allison M. Beal,
- Carol Capriotti,
- Leonard Azzarano,
- Debra Comroe,
- Michael Adam,
- Patrick Moore
- Published: February 25, 2025
- https://doi.org/10.1371/journal.pone.0319216