Chemical nucleases are a robust alternative for RNase H cleavage of human ribosomal RNA

• Hagen Wesseling ,

  Contributed equally to this work with: Hagen Wesseling, Dennis Krug

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Frankfurt/M, Germany

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• Dennis Krug ,

  Contributed equally to this work with: Hagen Wesseling, Dennis Krug

  Roles Formal analysis, Investigation

  Affiliation Institute for Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Frankfurt/M, Germany

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• Marvin Wehrheim,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Frankfurt/M, Germany

  https://orcid.org/0009-0007-5495-6736

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• Michael W. Göbel,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft

  Affiliation Institute for Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Frankfurt/M, Germany

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• Stefanie Kaiser

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft

  * E-mail: stefanie.kaiser@pharmchem.uni-frankfurt.de

  Affiliation Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Frankfurt/M, Germany

  https://orcid.org/0000-0003-3224-7502

  ⨯