Hyaluronic acid: Function and location in the urothelial barrier for bladder pain syndrome/interstitial cystitis, an in vitro study

Charlotte J. van Ginkel; Cléo D.M. Baars; Dorien M. Tiemessen; Cornelius F.J. Jansen; Frank M.J. Martens; Jack A. Schalken; Dick A.W. Janssen

doi:10.1371/journal.pone.0318277

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Open Access

Peer-reviewed

Research Article

Hyaluronic acid: Function and location in the urothelial barrier for bladder pain syndrome/interstitial cystitis, an in vitro study

Charlotte J. van Ginkel ,

Contributed equally to this work with: Charlotte J. van Ginkel, Cléo D.M. Baars

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

* E-mail: charlottevanginkel@hotmail.com

Affiliation Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands

https://orcid.org/0000-0002-6416-7892

⨯
Cléo D.M. Baars ,

Contributed equally to this work with: Charlotte J. van Ginkel, Cléo D.M. Baars

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Dorien M. Tiemessen,

Roles Conceptualization, Data curation, Investigation, Writing – review & editing

Affiliation Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands

https://orcid.org/0000-0002-5529-9113

⨯
Cornelius F.J. Jansen,

Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Frank M.J. Martens,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands

https://orcid.org/0000-0002-5883-7116

⨯
Jack A. Schalken,

Roles Conceptualization, Data curation, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands

https://orcid.org/0000-0001-8274-7797

⨯
Dick A.W. Janssen

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands
⨯

Hyaluronic acid: Function and location in the urothelial barrier for bladder pain syndrome/interstitial cystitis, an in vitro study

Charlotte J. van Ginkel,
Cléo D.M. Baars,
Dorien M. Tiemessen,
Cornelius F.J. Jansen,
Frank M.J. Martens,
Jack A. Schalken,
Dick A.W. Janssen

Published: February 26, 2025
https://doi.org/10.1371/journal.pone.0318277

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Inflammation
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Urothelium
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Gene expression
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