Integration of pharmacodynamics, network pharmacology and metabolomics to elucidate the effect and mechanism of Jingfang Granule in the treatment of Paraquat induced Pulmonary fibrosis

Rujing Yue; Tianye Yang; Dejun Niu; Zhen Zeng; Xishuang Wang; Lihong Pan; Jingchun Yao

doi:10.1371/journal.pone.0318246

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Open Access

Peer-reviewed

Research Article

Integration of pharmacodynamics, network pharmacology and metabolomics to elucidate the effect and mechanism of Jingfang Granule in the treatment of Paraquat induced Pulmonary fibrosis

Rujing Yue ,

Contributed equally to this work with: Rujing Yue

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd, Linyi, China
⨯
Tianye Yang ,

Roles Formal analysis, Methodology

¶‡ TY, DN, and ZZ, XW authors also contributed equally to this work.

Affiliation Department of Medicine and Pharmacy, Wuhan University, Wuhan, Hubei, China

https://orcid.org/0000-0001-7399-5086

⨯
Dejun Niu ,

Roles Data curation, Formal analysis, Visualization

¶‡ TY, DN, and ZZ, XW authors also contributed equally to this work.

Affiliation State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd, Linyi, China
⨯
Zhen Zeng ,

Roles Data curation, Methodology, Validation

¶‡ TY, DN, and ZZ, XW authors also contributed equally to this work.

Affiliation State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd, Linyi, China
⨯
Xishuang Wang ,

Roles Data curation, Software, Validation

¶‡ TY, DN, and ZZ, XW authors also contributed equally to this work.

Affiliation State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd, Linyi, China
⨯
Lihong Pan ,

Roles Software, Supervision, Visualization

* E-mail: panlihong2003@126.com (LP); yaojingchun@yeah.net (JY)

Affiliation State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd, Linyi, China

https://orcid.org/0000-0002-2213-5606

⨯
Jingchun Yao

Roles Conceptualization, Resources, Supervision

* E-mail: panlihong2003@126.com (LP); yaojingchun@yeah.net (JY)

Affiliation State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd, Linyi, China
⨯

Integration of pharmacodynamics, network pharmacology and metabolomics to elucidate the effect and mechanism of Jingfang Granule in the treatment of Paraquat induced Pulmonary fibrosis

Rujing Yue,
Tianye Yang,
Dejun Niu,
Zhen Zeng,
Xishuang Wang,
Lihong Pan,
Jingchun Yao

Published: February 18, 2025
https://doi.org/10.1371/journal.pone.0318246

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