Single-cell RNA-seq reveals disease-specific CD8+ T cell clonal expansion and a high frequency of transcriptionally distinct double-negative T cells in diabetic NOD mice

• Md Zohorul Islam ,

  Contributed equally to this work with: Md Zohorul Islam, Sam Zimmerman

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Experimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark, CSIRO Health & Biosecurity, Australian Centre for Disease Preparedness, Geelong, Victoria, Australia

  https://orcid.org/0000-0002-2015-5195

  ⨯
• Sam Zimmerman ,

  Contributed equally to this work with: Md Zohorul Islam, Sam Zimmerman

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization

  Affiliations Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Alexis Lindahl,

  Roles Formal analysis, Investigation, Validation, Visualization

  Affiliation Department of Animal Science, University of Illinois, Urbana-Champaign, Illinois, United States of America

  ⨯
• Jon Weidanz,

  Roles Supervision

  Affiliations Department of Kinesiology, The University of Texas at Arlington, Texas, United States of America, Department of Bioengineering, The University of Texas at Arlington, Texas, United States of America

  ⨯
• Jose Ordovas-Montanes,

  Roles Project administration, Resources, Supervision

  Affiliations Division of Gastroenterology, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Aleksandar Kostic ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: robben@illinois.edu (MWR), jacob.luber@uta.edu (JML), aleksandar.kostic@joslin.harvard.edu (ADK)

  Affiliations Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Jacob Luber ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: robben@illinois.edu (MWR), jacob.luber@uta.edu (JML), aleksandar.kostic@joslin.harvard.edu (ADK)

  ¶‡ These authors also contributed equally to this work.

  Affiliation Department of Computer Science and Engineering, The University of Texas at Arlington, United States of America

  https://orcid.org/0000-0001-5268-5732

  ⨯
• Michael Robben

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: robben@illinois.edu (MWR), jacob.luber@uta.edu (JML), aleksandar.kostic@joslin.harvard.edu (ADK)

  ¶‡ These authors also contributed equally to this work.

  Affiliations Department of Animal Science, University of Illinois, Urbana-Champaign, Illinois, United States of America, Department of Computer Science and Engineering, The University of Texas at Arlington, United States of America

  https://orcid.org/0000-0002-5322-9947

  ⨯