DNA methylation differences stratified by normalized fetal/placental weight ratios suggest neurodevelopmental deficits in neonates with congenital heart disease

• Marin Jacobwitz ,

  Contributed equally to this work with: Marin Jacobwitz, Michael Xie

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jacobwitzm@chop.edu

  Affiliation Developing Brain Institute, Children’s National Hospital, Washington, DC, United States of America

  https://orcid.org/0000-0002-9489-6594

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• Michael Xie ,

  Contributed equally to this work with: Marin Jacobwitz, Michael Xie

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Biomedical and Health Informatics (DBHi), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Jamie Catalano,

  Roles Methodology, Validation, Writing – review & editing, Formal analysis

  Affiliations Developing Brain Institute, Children’s National Hospital, Washington, DC, United States of America, Clinical Futures, PolicyLab, LifeSpan Brain Institute, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-7822-590X

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• Ingo Helbig,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Department of Biomedical and Health Informatics (DBHi), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Division of Neurology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, The Epilepsy Neurogenetics Initiative (ENGIN), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, The Department of Neurology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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• J. William Gaynor,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliation Division of Cardiothoracic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-7955-5604

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• Nancy Burnham,

  Roles Data curation, Writing – review & editing

  Affiliation Division of Cardiothoracic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Rebecca L. Linn,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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• Juliana Gebb,

  Roles Conceptualization, Writing – review & editing

  Affiliations The Richard D. Wood, Jr Center for Fetal Diagnosis and Treatment, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, The Perelman School of Medicine of The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Mark W. Russell,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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• Hakon Hakonarson,

  Roles Data curation, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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• Barbara H. Chaiyachati,

  Roles Conceptualization, Investigation, Methodology, Resources, Visualization, Writing – review & editing

  Affiliations Clinical Futures, PolicyLab, LifeSpan Brain Institute, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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• Ana G. Cristancho

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Division of Neurology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, The Department of Neurology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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