Alpinetin protects against iron overload related osteoarthritis via NRF2/HO-1 pathway

Dongling Cai; Zhaofeng Pan; Shaocong Li; Qi He; Baihao Chen; Miao Li; Jiacong Xiao; Fancheng Wan; Haibin Wang; Chi Zhou

doi:10.1371/journal.pone.0317930

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Open Access

Peer-reviewed

Research Article

Alpinetin protects against iron overload related osteoarthritis via NRF2/HO-1 pathway

Dongling Cai ,

Contributed equally to this work with: Dongling Cai, Zhaofeng Pan, Shaocong Li

Roles Writing – original draft

Affiliation Department of Orthopaedics, Panyu Hospital of Chinese Medicine, Guangzhou, China
⨯
Zhaofeng Pan ,

Contributed equally to this work with: Dongling Cai, Zhaofeng Pan, Shaocong Li

Roles Writing – original draft

Affiliation The School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China
⨯
Shaocong Li ,

Contributed equally to this work with: Dongling Cai, Zhaofeng Pan, Shaocong Li

Roles Writing – original draft

Affiliation The School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China
⨯
Qi He,

Roles Writing – original draft

Affiliation The School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China
⨯
Baihao Chen,

Roles Writing – original draft

Affiliation The School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China
⨯
Miao Li,

Roles Writing – original draft

Affiliation The School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China
⨯
Jiacong Xiao,

Roles Writing – original draft

Affiliation The School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China
⨯
Fancheng Wan,

Roles Writing – original draft

Affiliation The School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, P.R.China
⨯
Haibin Wang ,

Roles Writing – original draft

* E-mail: hipman@163.com (HW); zcmzy1@163.com (CZ)

Affiliation Department of Orthopaedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Chi Zhou

Roles Writing – original draft

* E-mail: hipman@163.com (HW); zcmzy1@163.com (CZ)

Affiliation Department of Orthopaedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China

https://orcid.org/0000-0003-1905-9494

⨯

Alpinetin protects against iron overload related osteoarthritis via NRF2/HO-1 pathway

Dongling Cai,
Zhaofeng Pan,
Shaocong Li,
Qi He,
Baihao Chen,
Miao Li,
Jiacong Xiao,
Fancheng Wan,
Haibin Wang,
Chi Zhou

Published: June 2, 2025
https://doi.org/10.1371/journal.pone.0317930

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