Integrated metagenomic and metabolomic analyses of the effects of total flavonoids of Rhizoma Drynariae on reducing ovariectomized-induced osteoporosis by regulating gut microbiota and related metabolites

Qiuyue Li; Xuelin Wu; Xinyu Niu; Zhangjingze Yu; Shengjie Fang; Xuelei Chu; Jia Zhu; Qinghui Song; Chengzhi Hou; Xu Wei

doi:10.1371/journal.pone.0317832

Loading metrics

Open Access

Peer-reviewed

Research Article

Integrated metagenomic and metabolomic analyses of the effects of total flavonoids of Rhizoma Drynariae on reducing ovariectomized-induced osteoporosis by regulating gut microbiota and related metabolites

Qiuyue Li ,

Contributed equally to this work with: Qiuyue Li, Xuelin Wu

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Writing – original draft

Affiliation Pharmacological Laboratory of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Xuelin Wu ,

Contributed equally to this work with: Qiuyue Li, Xuelin Wu

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliation Pharmacological Laboratory of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Xinyu Niu,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Pharmacological Laboratory of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Zhangjingze Yu,

Roles Formal analysis, Investigation, Resources, Visualization, Writing – original draft

Affiliation Pharmacological Laboratory of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Shengjie Fang,

Roles Formal analysis, Resources, Validation, Visualization

Affiliation Department of Education, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Xuelei Chu,

Roles Conceptualization, Formal analysis, Resources, Visualization

Affiliation Department of Education, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Jia Zhu,

Roles Conceptualization, Formal analysis, Resources, Visualization

Affiliation Pharmacological Laboratory of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Qinghui Song,

Roles Formal analysis, Resources, Validation, Visualization

Affiliation Pharmacological Laboratory of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Chengzhi Hou ,

Roles Formal analysis, Methodology, Validation, Writing – review & editing

* E-mail: weixu.007@163.com (XW); houcz2010@163.com (CH)

Affiliation Department of Education, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Xu Wei

Roles Formal analysis, Funding acquisition, Methodology, Writing – review & editing

* E-mail: weixu.007@163.com (XW); houcz2010@163.com (CH)

Affiliation Department of Academic Development, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China

https://orcid.org/0000-0001-6723-9604

⨯

Integrated metagenomic and metabolomic analyses of the effects of total flavonoids of Rhizoma Drynariae on reducing ovariectomized-induced osteoporosis by regulating gut microbiota and related metabolites

Qiuyue Li,
Xuelin Wu,
Xinyu Niu,
Zhangjingze Yu,
Shengjie Fang,
Xuelei Chu,
Jia Zhu,
Qinghui Song,
Chengzhi Hou,
Xu Wei

Published: February 14, 2025
https://doi.org/10.1371/journal.pone.0317832

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Gut bacteria
Is the Subject Area "Gut bacteria" applicable to this article?

Thanks for your feedback.
Metabolic pathways
Is the Subject Area "Metabolic pathways" applicable to this article?

Thanks for your feedback.
Metabolites
Is the Subject Area "Metabolites" applicable to this article?

Thanks for your feedback.
Ovariectomy
Is the Subject Area "Ovariectomy" applicable to this article?

Thanks for your feedback.
Metabolomics
Is the Subject Area "Metabolomics" applicable to this article?

Thanks for your feedback.
Phenylalanine
Is the Subject Area "Phenylalanine" applicable to this article?

Thanks for your feedback.
Metabolic analysis
Is the Subject Area "Metabolic analysis" applicable to this article?

Thanks for your feedback.
Bone density
Is the Subject Area "Bone density" applicable to this article?

Thanks for your feedback.