Transcriptomic analysis of human primary T cells after short-term leucine-deprivation and evaluation of kinase GCN2’s role in regulating differential gene expression

Aurore Dougé; Gwendal Cueff; Céline Keime; Valérie Carraro; Céline Jousse; Paul Rouzaire; Alain Bruhat

doi:10.1371/journal.pone.0317505

Loading metrics

Open Access

Peer-reviewed

Research Article

Transcriptomic analysis of human primary T cells after short-term leucine-deprivation and evaluation of kinase GCN2’s role in regulating differential gene expression

Aurore Dougé ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft

* E-mail: adouge@chu-clermontferrand.fr

Affiliations Service d’oncologie médicale, CHU Gabriel Montpied, Clermont-Ferrand, France, Université Clermont Auvergne, EA Chelter 7453, Clermont-Ferrand, France

https://orcid.org/0000-0001-7737-3735

⨯
Gwendal Cueff,

Roles Data curation, Formal analysis, Software

Affiliation Université Clermont Auvergne, INRAE, UNH, UMR1019, Clermont-Ferrand, France
⨯
Céline Keime,

Roles Data curation, Formal analysis

Affiliation IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
⨯
Valérie Carraro,

Roles Investigation

Affiliation Université Clermont Auvergne, INRAE, UNH, UMR1019, Clermont-Ferrand, France
⨯
Céline Jousse,

Roles Data curation, Formal analysis, Validation

Affiliation Université Clermont Auvergne, INRAE, UNH, UMR1019, Clermont-Ferrand, France
⨯
Paul Rouzaire ,

Contributed equally to this work with: Paul Rouzaire, Alain Bruhat

Roles Conceptualization, Supervision

¶‡ AB and PR are Joint Senior Authors.

Affiliations Université Clermont Auvergne, EA Chelter 7453, Clermont-Ferrand, France, Université Clermont Auvergne, Clermont-Ferrand, France, Service d’histocompatibilité et d’immunogénétique CHU Gabriel Montpied, Clermont-Ferrand, France
⨯
Alain Bruhat

Contributed equally to this work with: Paul Rouzaire, Alain Bruhat

Roles Conceptualization, Supervision

¶‡ AB and PR are Joint Senior Authors.

Affiliation Université Clermont Auvergne, INRAE, UNH, UMR1019, Clermont-Ferrand, France
⨯

Transcriptomic analysis of human primary T cells after short-term leucine-deprivation and evaluation of kinase GCN2’s role in regulating differential gene expression

Aurore Dougé,
Gwendal Cueff,
Céline Keime,
Valérie Carraro,
Céline Jousse,
Paul Rouzaire,
Alain Bruhat

Published: February 18, 2025
https://doi.org/10.1371/journal.pone.0317505

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Leucine
Is the Subject Area "Leucine" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Amino acid analysis
Is the Subject Area "Amino acid analysis" applicable to this article?

Thanks for your feedback.
Cell metabolism
Is the Subject Area "Cell metabolism" applicable to this article?

Thanks for your feedback.
Gene ontologies
Is the Subject Area "Gene ontologies" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
Cellular stress responses
Is the Subject Area "Cellular stress responses" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.