Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice

Giada Lavigna; Anna Grasso; Chiara Pasini; Valentina Grande; Laura Mignogna; Elena Restelli; Antonio Masone; Claudia Fracasso; Jacopo Lucchetti; Marco Gobbi; Roberto Chiesa

doi:10.1371/journal.pone.0317404

Loading metrics

Open Access

Peer-reviewed

Research Article

Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice

Giada Lavigna,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Anna Grasso,

Roles Investigation

Affiliation Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Chiara Pasini,

Roles Investigation

Affiliation Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Valentina Grande,

Roles Investigation

Current address: Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany

Affiliation Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Laura Mignogna,

Roles Investigation

Affiliation Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Elena Restelli,

Roles Investigation

Current address: Human Technopole, Milan, Italy

Affiliation Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Antonio Masone,

Roles Investigation

Affiliation Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

https://orcid.org/0000-0001-8357-5931

⨯
Claudia Fracasso,

Roles Investigation

Affiliation Department of Molecular Biochemistry and Pharmacology, Laboratory of Pharmacodynamics and Pharmacokinetics, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Jacopo Lucchetti,

Roles Investigation

Affiliation Department of Molecular Biochemistry and Pharmacology, Laboratory of Pharmacodynamics and Pharmacokinetics, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

https://orcid.org/0000-0002-9503-8786

⨯
Marco Gobbi,

Roles Formal analysis, Supervision, Writing – review & editing

Affiliation Department of Molecular Biochemistry and Pharmacology, Laboratory of Pharmacodynamics and Pharmacokinetics, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⨯
Roberto Chiesa

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: roberto.chiesa@marionegri.it

Affiliation Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

https://orcid.org/0000-0002-3842-3733

⨯

Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice

Giada Lavigna,
Anna Grasso,
Chiara Pasini,
Valentina Grande,
Laura Mignogna,
Elena Restelli,
Antonio Masone,
Claudia Fracasso,
Jacopo Lucchetti,
Marco Gobbi

Published: January 13, 2025
https://doi.org/10.1371/journal.pone.0317404

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Signal inhibition
Is the Subject Area "Signal inhibition" applicable to this article?

Thanks for your feedback.
Animal performance
Is the Subject Area "Animal performance" applicable to this article?

Thanks for your feedback.
Neuroprotectives
Is the Subject Area "Neuroprotectives" applicable to this article?

Thanks for your feedback.
Pharmacokinetics
Is the Subject Area "Pharmacokinetics" applicable to this article?

Thanks for your feedback.
Luciferase
Is the Subject Area "Luciferase" applicable to this article?

Thanks for your feedback.
Purkinje cells
Is the Subject Area "Purkinje cells" applicable to this article?

Thanks for your feedback.
Stress signaling cascade
Is the Subject Area "Stress signaling cascade" applicable to this article?

Thanks for your feedback.