Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection

• Bryce M. Warner,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

  ⨯
• Robert Vendramelli,

  Roles Data curation, Investigation, Methodology

  Affiliation Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

  https://orcid.org/0000-0002-9131-2602

  ⨯
• Amrit S. Boese,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

  https://orcid.org/0000-0003-0235-4710

  ⨯
• Jonathan Audet,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

  ⨯
• Nikesh Tailor,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

  ⨯
• Courtney Meilleur,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

  ⨯
• Nathan Glowach,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada

  ⨯
• Marnie Willman,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada

  ⨯
• Thang Truong,

  Roles Investigation, Methodology

  Affiliation Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

  ⨯
• Estella Moffat,

  Roles Investigation, Methodology

  Affiliation National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada

  ⨯
• Kevin Tierney,

  Roles Investigation, Methodology, Resources

  Affiliation Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

  ⨯
• Beata Kosak,

  Roles Project administration, Resources

  Affiliation Orion Biotechnology Polska, Krakow, Poland

  ⨯
• Irfan Dhanidina,

  Roles Project administration, Resources

  Affiliation Orion Biotechnology, Ottawa, Ontario, Canada

  ⨯
• Jarret Engstrom,

  Roles Funding acquisition, Methodology, Project administration

  Affiliation Orion Biotechnology, Ottawa, Ontario, Canada

  ⨯
• Bozena Korczak,

  Roles Conceptualization, Methodology, Project administration, Writing – review & editing

  Affiliation Orion Biotechnology Polska, Krakow, Poland

  ⨯
• Ian McGowan,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Orion Biotechnology Polska, Krakow, Poland

  ⨯
• Carissa Embury-Hyatt,

  Roles Formal analysis, Investigation, Resources, Supervision, Writing – review & editing

  Affiliation National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada

  ⨯
•  [ ... ],
• Darwyn Kobasa

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: darwyn.kobasa@phac-aspc.gc.ca

  Affiliations Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada

  https://orcid.org/0000-0002-6371-7493

  ⨯
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