APOE4 and infectious diseases jointly contribute to brain glucose hypometabolism, a biomarker of Alzheimer’s pathology: New findings from the ADNI

Aravind Lathika Rajendrakumar; Konstantin G. Arbeev; Olivia Bagley; Matt Duan; Anatoliy I. Yashin; Svetlana Ukraintseva; for the Alzheimer’s Disease Neuroimaging Initiative

doi:10.1371/journal.pone.0316808

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Open Access

Peer-reviewed

Research Article

APOE4 and infectious diseases jointly contribute to brain glucose hypometabolism, a biomarker of Alzheimer’s pathology: New findings from the ADNI

Aravind Lathika Rajendrakumar ,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

* E-mail: svetlana.ukraintseva@duke.edu (SU); arl75@duke.edu (ALR)

Affiliation Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, United States of America

https://orcid.org/0000-0002-4286-7265

⨯
Konstantin G. Arbeev,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, United States of America
⨯
Olivia Bagley,

Roles Data curation

Affiliation Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, United States of America
⨯
Matt Duan,

Roles Data curation

Affiliation Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, United States of America
⨯
Anatoliy I. Yashin,

Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

Affiliation Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, United States of America
⨯
Svetlana Ukraintseva ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: svetlana.ukraintseva@duke.edu (SU); arl75@duke.edu (ALR)

Affiliation Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, United States of America
⨯
for the Alzheimer’s Disease Neuroimaging Initiative

¶Membership of the Alzheimer’s Disease Neuroimaging Initiative is listed in the Acknowledgments.

Affiliation Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, United States of America
⨯

APOE4 and infectious diseases jointly contribute to brain glucose hypometabolism, a biomarker of Alzheimer’s pathology: New findings from the ADNI

Aravind Lathika Rajendrakumar,
Konstantin G. Arbeev,
Olivia Bagley,
Matt Duan,
Anatoliy I. Yashin,
Svetlana Ukraintseva,
for the Alzheimer’s Disease Neuroimaging Initiative

Published: January 7, 2025
https://doi.org/10.1371/journal.pone.0316808

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