MAP1LC3C repression reduces CIITA- and HLA class II expression in non-small cell lung cancer

Lydie M. O. Barbeau; Nicky A. Beelen; Kim G. Savelkouls; Tom G. H. Keulers; Lotte Wieten; Kasper M. A. Rouschop

doi:10.1371/journal.pone.0316716

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Open Access

Peer-reviewed

Research Article

MAP1LC3C repression reduces CIITA- and HLA class II expression in non-small cell lung cancer

Lydie M. O. Barbeau,

Roles Conceptualization, Investigation, Writing – original draft

Affiliation Department of Radiation Oncology (Maastro), GROW - School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands
⨯
Nicky A. Beelen,

Roles Investigation, Writing – review & editing

Affiliations Department of Internal Medicine, GROW - School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands, Department of Transplantation Immunology, GROW - School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands
⨯
Kim G. Savelkouls,

Roles Investigation

Affiliation Department of Radiation Oncology (Maastro), GROW - School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands
⨯
Tom G. H. Keulers,

Roles Conceptualization, Investigation, Supervision

Affiliation Department of Radiation Oncology (Maastro), GROW - School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands
⨯
Lotte Wieten,

Roles Supervision, Writing – review & editing

Affiliation Department of Transplantation Immunology, GROW - School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands
⨯
Kasper M. A. Rouschop

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: kasper.rouschop@maastrichtuniversity.nl

Affiliation Department of Radiation Oncology (Maastro), GROW - School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands

https://orcid.org/0000-0002-4208-5415

⨯

MAP1LC3C repression reduces CIITA- and HLA class II expression in non-small cell lung cancer

Lydie M. O. Barbeau,
Nicky A. Beelen,
Kim G. Savelkouls,
Tom G. H. Keulers,
Lotte Wieten,
Kasper M. A. Rouschop

Published: February 10, 2025
https://doi.org/10.1371/journal.pone.0316716

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Lung and intrathoracic tumors
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Non-small cell lung cancer
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Gene expression
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Breast cancer
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Immune response
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Squamous cell lung carcinoma
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Head and neck cancers
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Immune cells
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