Obesity-induced activation of NADPH oxidase 2 prolongs cardiac repolarization via inhibiting K+ currents

Bin Li; Yating Chen; Maoxiang Zhao; Zhijie Chen; Zhuhui Lin; Jie Liu; Xueping Wang; Jiancheng Zhang; Yang Li

doi:10.1371/journal.pone.0316701

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Open Access

Peer-reviewed

Research Article

Obesity-induced activation of NADPH oxidase 2 prolongs cardiac repolarization via inhibiting K⁺ currents

Bin Li ,

Contributed equally to this work with: Bin Li, Yating Chen

Roles Investigation, Methodology, Resources, Software

Affiliations Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China, The Eighth Medical Center of PLA General Hospital, Beijing, China, Senior Department of Cardiology, the Sixth Medical Center of PLA General Hospital, Beijing, China
⨯
Yating Chen ,

Contributed equally to this work with: Bin Li, Yating Chen

Roles Data curation, Formal analysis, Investigation

Affiliations Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China, Senior Department of Cardiology, the Sixth Medical Center of PLA General Hospital, Beijing, China
⨯
Maoxiang Zhao,

Roles Resources, Software, Supervision

Affiliations Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China, Senior Department of Cardiology, the Sixth Medical Center of PLA General Hospital, Beijing, China
⨯
Zhijie Chen,

Roles Supervision, Validation

Affiliation Department of Cardiology, Fujian Provincial Hospital, Provincial Clinical Medicine College of Fujian Medical University, Fuzhou, China
⨯
Zhuhui Lin,

Roles Validation, Visualization

Affiliation Department of Cardiology, Fujian Provincial Hospital, Provincial Clinical Medicine College of Fujian Medical University, Fuzhou, China
⨯
Jie Liu,

Roles Writing – original draft

Affiliation Senior Department of Cardiology, the Sixth Medical Center of PLA General Hospital, Beijing, China
⨯
Xueping Wang,

Roles Writing – review & editing

Affiliation Medical Innovation Research Department of PLA General Hospital, Beijing, China
⨯
Jiancheng Zhang ,

Roles Writing – review & editing

* E-mail: liyangbsh@163.com (YL); fjzhangjiancheng@126.com (JZ)

Affiliation Department of Cardiology, Fujian Provincial Hospital, Provincial Clinical Medicine College of Fujian Medical University, Fuzhou, China
⨯
Yang Li

Roles Writing – original draft

* E-mail: liyangbsh@163.com (YL); fjzhangjiancheng@126.com (JZ)

Affiliations Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China, Senior Department of Cardiology, the Sixth Medical Center of PLA General Hospital, Beijing, China

https://orcid.org/0000-0001-5706-1830

⨯

Obesity-induced activation of NADPH oxidase 2 prolongs cardiac repolarization via inhibiting K⁺ currents

Bin Li,
Yating Chen,
Maoxiang Zhao,
Zhijie Chen,
Zhuhui Lin,
Jie Liu,
Xueping Wang,
Jiancheng Zhang,
Yang Li

Published: December 31, 2024
https://doi.org/10.1371/journal.pone.0316701

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Obesity
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Muscle cells
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Diet
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Electrocardiography
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Potassium channels
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Electrophysiology
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Heart
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Cardiac electrophysiology
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