4-Hydroxy-2-nonenal causes nuclear accumulation of p62 by inhibiting Xpo1 and promoting the proteolytic pathway in the nucleus

• Emi Kayama ,

  Contributed equally to this work with: Emi Kayama, Ning Baoshuo

  Roles Data curation, Investigation

  Affiliation Department of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan

  ⨯
• Ning Baoshuo ,

  Contributed equally to this work with: Emi Kayama, Ning Baoshuo

  Roles Data curation, Investigation

  Affiliation Department of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan

  ⨯
• Rinna Tatsuno,

  Roles Data curation, Investigation

  Affiliation Department of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan

  ⨯
• Kanako Nishi,

  Roles Data curation, Investigation

  Affiliation Department of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan

  ⨯
• Elsayed S. I. Mohammed,

  Roles Data curation, Investigation

  Affiliations Department of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan, Department of Histology and Cytology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt

  ⨯
• Yumi Abiko,

  Roles Methodology, Supervision

  Affiliation Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

  ⨯
• Toru Yanagawa,

  Roles Funding acquisition, Supervision

  Affiliation Department of Clinical Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan

  https://orcid.org/0000-0003-0868-2563

  ⨯
• Satoru Takahashi,

  Roles Supervision

  Affiliation Department of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan

  ⨯
• Eiji Warabi

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Validation, Visualization, Writing – original draft

  * E-mail: warabi-e@md.tsukuba.ac.jp

  Affiliation Department of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan

  ⨯