Butyric acid alleviates LPS-induced intestinal mucosal barrier damage by inhibiting the RhoA/ROCK2/MLCK signaling pathway in Caco2 cells

Luqiong Liu; Tong Chen; Zhenrong Xie; Yongjin Zhang; Chenglu He; Yongkun Huang

doi:10.1371/journal.pone.0316362

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Open Access

Peer-reviewed

Research Article

Butyric acid alleviates LPS-induced intestinal mucosal barrier damage by inhibiting the RhoA/ROCK2/MLCK signaling pathway in Caco2 cells

Luqiong Liu ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

* E-mail: lluqiong@163.com (LL); hykkmyncnwd@163.com (YH)

Affiliations Kunming Medical University, Kunming, Yunnan, China, Department of Pediatrics, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

https://orcid.org/0000-0001-7336-1526

⨯
Tong Chen,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Centre for Experimental Studies and Research, the first Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Zhenrong Xie,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation BioBank, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Yongjin Zhang,

Roles Data curation, Investigation, Methodology

Affiliation Centre for Experimental Studies and Research, the first Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Chenglu He,

Roles Data curation, Formal analysis

Affiliation Department of Laboratory Medicine, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Yongkun Huang

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – review & editing

* E-mail: lluqiong@163.com (LL); hykkmyncnwd@163.com (YH)

Affiliation Department of Pediatrics, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯

Butyric acid alleviates LPS-induced intestinal mucosal barrier damage by inhibiting the RhoA/ROCK2/MLCK signaling pathway in Caco2 cells

Luqiong Liu,
Tong Chen,
Zhenrong Xie,
Yongjin Zhang,
Chenglu He,
Yongkun Huang

Published: December 26, 2024
https://doi.org/10.1371/journal.pone.0316362

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Gastrointestinal tract
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Permeability
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Tight junctions
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