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Open Access

Peer-reviewed

Research Article

Upregulated LIMD1 alleviates pressure overload-induced cardiac hypertrophy via inhibits YAP1/AKT/GSK3β signaling

Fengwen Xie ,

Contributed equally to this work with: Fengwen Xie, Bin Yuan

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Thoracic Surgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China
⨯
Bin Yuan ,

Contributed equally to this work with: Fengwen Xie, Bin Yuan

Roles Formal analysis, Investigation, Resources

Affiliation Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China
⨯
Ye Zhang,

Roles Investigation, Resources, Software

Affiliation Department of Thoracic Surgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China
⨯
Liru Chen,

Roles Formal analysis, Methodology, Resources

Affiliation Department of Thoracic Surgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China
⨯
Yingmei Zhong,

Roles Methodology, Resources, Software

Affiliation Department of Thoracic Surgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China
⨯
Quan Xu

Roles Project administration, Writing – review & editing

* E-mail: xuquan7210@163.com

Affiliation Department of Thoracic Surgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China

https://orcid.org/0000-0001-9604-7601

⨯

Upregulated LIMD1 alleviates pressure overload-induced cardiac hypertrophy via inhibits YAP1/AKT/GSK3β signaling

Fengwen Xie,
Bin Yuan,
Ye Zhang,
Liru Chen,
Yingmei Zhong,
Quan Xu

x

Published: February 12, 2025
https://doi.org/10.1371/journal.pone.0316149

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Cardiac hypertrophy
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Heart
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Hyperexpression techniques
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Fibrosis
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Cardiomyocytes
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Cardiovascular physiology
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Heart failure
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Stress signaling cascade
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