Integrated in silico and in vitro exploration of the anti-VEGFR-2 activities of a semisynthetic xanthine alkaloid inhibiting breast cancer

• Eslam B. Elkaeed,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia

  ⨯
• Hazem Elkady ,

  Roles Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

  * E-mail: hazemelkady@azhar.edu.eg (HE); ametwaly@azhar.edu.eg (AMM); ibrahimeissa@azhar.edu.eg (IHE)

  Affiliation Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  https://orcid.org/0000-0003-0893-6703

  ⨯
• Ahmed M. Khattab,

  Roles Methodology

  Affiliation Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  ⨯
• Reda G. Yousef,

  Roles Investigation, Methodology

  Affiliations Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Merit University, Sohag, Egypt

  ⨯
• Hanan A. Al-ghulikah,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

  ⨯
• Dalal Z. Husein,

  Roles Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Chemistry Department, Faculty of Science, New Valley University, El-Kharja, Egypt

  ⨯
• Ibrahim M. Ibrahim,

  Roles Methodology, Software, Validation, Writing – original draft

  Affiliation Biophysics Department, Faculty of Science, Cairo University, Cairo, Egypt

  ⨯
• Mohamed A. Elkady,

  Roles Investigation, Methodology

  Affiliation Biochemistry & Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  ⨯
• Ahmed M. Metwaly ,

  Roles Conceptualization, Data curation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: hazemelkady@azhar.edu.eg (HE); ametwaly@azhar.edu.eg (AMM); ibrahimeissa@azhar.edu.eg (IHE)

  Affiliation Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  https://orcid.org/0000-0001-8566-1980

  ⨯
• Ibrahim H. Eissa

  Roles Conceptualization, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: hazemelkady@azhar.edu.eg (HE); ametwaly@azhar.edu.eg (AMM); ibrahimeissa@azhar.edu.eg (IHE)

  Affiliation Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  ⨯