The effect of IL-1β inhibitor canakinumab (Ilaris®) on IL-6 production in human skeletal muscle cells

Anna Cordeiro-Santanach; Fiorella Morales; Maria del Carmen Parquet; Kitipong Uaesoontrachoon; Joyce Rowsell; Jordan Warford; Wilson Wu; Pia Elustondo; Eric P. Hoffman; Kanneboyina Nagaraju

doi:10.1371/journal.pone.0316110

Loading metrics

Open Access

Peer-reviewed

Research Article

The effect of IL-1β inhibitor canakinumab (Ilaris®) on IL-6 production in human skeletal muscle cells

Anna Cordeiro-Santanach,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation AGADA Biosciences Inc., Halifax, Nova Scotia, Canada
⨯
Fiorella Morales,

Roles Investigation, Methodology

Affiliation AGADA Biosciences Inc., Halifax, Nova Scotia, Canada
⨯
Maria del Carmen Parquet,

Roles Investigation, Methodology

Affiliation AGADA Biosciences Inc., Halifax, Nova Scotia, Canada
⨯
Kitipong Uaesoontrachoon,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation AGADA Biosciences Inc., Halifax, Nova Scotia, Canada
⨯
Joyce Rowsell,

Roles Formal analysis, Investigation, Methodology

Affiliation AGADA Biosciences Inc., Halifax, Nova Scotia, Canada
⨯
Jordan Warford,

Roles Formal analysis, Investigation, Methodology

Affiliation AGADA Biosciences Inc., Halifax, Nova Scotia, Canada
⨯
Wilson Wu,

Roles Data curation, Formal analysis, Investigation

Affiliation AGADA Biosciences Inc., Halifax, Nova Scotia, Canada
⨯
Pia Elustondo,

Roles Data curation, Supervision, Writing – review & editing

Affiliation AGADA Biosciences Inc., Halifax, Nova Scotia, Canada
⨯
Eric P. Hoffman,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliations AGADA Biosciences Inc., Halifax, Nova Scotia, Canada, School of Pharmacy and Pharmaceutical Sciences, Binghamton University, State University of New York, New York, United States of America
⨯
Kanneboyina Nagaraju

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: nagaraju@binghamton.edu

Affiliations AGADA Biosciences Inc., Halifax, Nova Scotia, Canada, School of Pharmacy and Pharmaceutical Sciences, Binghamton University, State University of New York, New York, United States of America
⨯

The effect of IL-1β inhibitor canakinumab (Ilaris®) on IL-6 production in human skeletal muscle cells

Anna Cordeiro-Santanach,
Fiorella Morales,
Maria del Carmen Parquet,
Kitipong Uaesoontrachoon,
Joyce Rowsell,
Jordan Warford,
Wilson Wu,
Pia Elustondo,
Eric P. Hoffman,
Kanneboyina Nagaraju

Published: March 6, 2025
https://doi.org/10.1371/journal.pone.0316110

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Myoblasts
Is the Subject Area "Myoblasts" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Skeletal muscles
Is the Subject Area "Skeletal muscles" applicable to this article?

Thanks for your feedback.
Analysis of variance
Is the Subject Area "Analysis of variance" applicable to this article?

Thanks for your feedback.
MTT assay
Is the Subject Area "MTT assay" applicable to this article?

Thanks for your feedback.
Cytokine therapy
Is the Subject Area "Cytokine therapy" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.