The landscape of alternative splicing in granulosa cells and a potential novel role of YAP1 in PCOS

Linlin Yang; Jianhua Chen; Hui Miao; Na Li; Huilin Bi; Ruizhi Feng; Congxiu Miao

doi:10.1371/journal.pone.0315750

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Open Access

Peer-reviewed

Research Article

The landscape of alternative splicing in granulosa cells and a potential novel role of YAP1 in PCOS

Linlin Yang ,

Roles Data curation, Formal analysis, Writing – original draft

¶‡ LY and JC are contributed equally to this work and share the first authorship.

Affiliation Department of Reproductive Genetics, Key Laboratory of Reproduction Engineer of Shanxi Health Committee, Heping Hospital of Changzhi Medical College, Changzhi, China
⨯
Jianhua Chen ,

Roles Formal analysis, Methodology, Writing – original draft

¶‡ LY and JC are contributed equally to this work and share the first authorship.

Affiliation State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China
⨯
Hui Miao,

Roles Data curation

Affiliation Department of Reproductive Genetics, Key Laboratory of Reproduction Engineer of Shanxi Health Committee, Heping Hospital of Changzhi Medical College, Changzhi, China
⨯
Na Li,

Roles Data curation

Affiliation Department of Reproductive Genetics, Key Laboratory of Reproduction Engineer of Shanxi Health Committee, Heping Hospital of Changzhi Medical College, Changzhi, China
⨯
Huilin Bi,

Roles Visualization

Affiliation Department of Reproductive Genetics, Key Laboratory of Reproduction Engineer of Shanxi Health Committee, Heping Hospital of Changzhi Medical College, Changzhi, China
⨯
Ruizhi Feng ,

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: ruizhifeng@njmu.edu.cn (RF); mcxms@163.com (CM)

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China, Reproductive Medical Center of Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, Innovation Center of Suzhou Nanjing Medical University, Suzhou, China

https://orcid.org/0000-0002-8928-5414

⨯
Congxiu Miao

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: ruizhifeng@njmu.edu.cn (RF); mcxms@163.com (CM)

Affiliation Department of Reproductive Genetics, Key Laboratory of Reproduction Engineer of Shanxi Health Committee, Heping Hospital of Changzhi Medical College, Changzhi, China
⨯

The landscape of alternative splicing in granulosa cells and a potential novel role of YAP1 in PCOS

Linlin Yang,
Jianhua Chen,
Hui Miao,
Na Li,
Huilin Bi,
Ruizhi Feng,
Congxiu Miao

Published: December 13, 2024
https://doi.org/10.1371/journal.pone.0315750

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Alternative splicing
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Polycystic ovary syndrome
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Granulosa cells
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Gene expression
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Endoplasmic reticulum
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DNA transcription
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Introns
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Protein domains
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