MiRNA-223-5p inhibits hypoxia-induced apoptosis of BMSCs and promotes repair in Legg-Calvé-Perthes disease by targeting CHAC2 and activating the Wnt/β-catenin signaling pathway

Jiafei Yang; Tianjiu Zhang; Xingtao Zhu; Zhexi He; Xu Jiang; Song Yu; Huajian Gu

doi:10.1371/journal.pone.0315230

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Open Access

Peer-reviewed

Research Article

MiRNA-223-5p inhibits hypoxia-induced apoptosis of BMSCs and promotes repair in Legg-Calvé-Perthes disease by targeting CHAC2 and activating the Wnt/β-catenin signaling pathway

Jiafei Yang,

Roles Conceptualization, Investigation, Project administration, Writing – original draft, Writing – review & editing

Affiliations School of Clinical Medicine, Guizhou Medical University, Guiyang, China, Department of Pediatric Surgery, The Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guiyang, China

https://orcid.org/0000-0001-7089-1978

⨯
Tianjiu Zhang,

Roles Formal analysis, Methodology, Validation

Affiliation Department of Pediatric Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi Medical University, Zunyi, China
⨯
Xingtao Zhu,

Roles Conceptualization, Investigation, Methodology

Affiliation Guizhou University of Traditional Chinese Medicine, Guiyang, China
⨯
Zhexi He,

Roles Conceptualization, Investigation, Methodology, Software

Affiliation Guizhou University of Traditional Chinese Medicine, Guiyang, China
⨯
Xu Jiang,

Roles Data curation, Software, Validation, Visualization

Affiliation Guizhou University of Traditional Chinese Medicine, Guiyang, China
⨯
Song Yu ,

Contributed equally to this work with: Song Yu, Huajian Gu

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: yusongabc@126.com (SY); huajiangu6@163.com (HG)

Affiliations School of Clinical Medicine, Guizhou Medical University, Guiyang, China, Zunyi Medical And Pharmaceutical College, Zunyi, China
⨯
Huajian Gu

Contributed equally to this work with: Song Yu, Huajian Gu

Roles Resources, Supervision, Writing – review & editing

* E-mail: yusongabc@126.com (SY); huajiangu6@163.com (HG)

Affiliations School of Clinical Medicine, Guizhou Medical University, Guiyang, China, Department of Pediatric Surgery, The Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guiyang, China
⨯

MiRNA-223-5p inhibits hypoxia-induced apoptosis of BMSCs and promotes repair in Legg-Calvé-Perthes disease by targeting CHAC2 and activating the Wnt/β-catenin signaling pathway

Jiafei Yang,
Tianjiu Zhang,
Xingtao Zhu,
Zhexi He,
Xu Jiang,
Song Yu,
Huajian Gu

Published: January 24, 2025
https://doi.org/10.1371/journal.pone.0315230

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Hypoxia
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