Utility of quantitative whole-body autoradiography (QWBA) and oxidative combustion (OC) analysis in the assessment of tissue distribution of [¹⁴C]Mefuparib (CVL218) in SD and LE rats

• Xinmei Li ,

  Roles Conceptualization, Investigation, Validation, Writing – original draft

  ¶‡ XL and FW contributed equally to this work and share first authorship.

  Affiliation Department of Pharmacy, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University, Kunming, China

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• Feiyu Wang ,

  Roles Conceptualization, Investigation, Validation, Writing – original draft

  ¶‡ XL and FW contributed equally to this work and share first authorship.

  Affiliations School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shanghai, China

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• Xinyue Zhang,

  Roles Data curation

  Affiliations School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shanghai, China

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• Xiaokun Shen,

  Roles Resources

  Affiliation Convalife (Shanghai) Co., Ltd., Shanghai, China

  ⨯
• Chunhao Yang,

  Roles Funding acquisition, Resources

  Affiliation Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shanghai, China

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• Yuandong Zheng ,

  Roles Conceptualization, Investigation, Validation

  * E-mail: xxdiao@simm.ac.cn (XD); ydzheng@simm.ac.cn (YZ)

  Affiliation Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shanghai, China

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• Xingxing Diao

  Roles Writing – review & editing

  * E-mail: xxdiao@simm.ac.cn (XD); ydzheng@simm.ac.cn (YZ)

  Affiliations School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shanghai, China

  https://orcid.org/0000-0002-7672-9952

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