The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells

Daniela Russo; Anna Spina; Luigi Portella; Anna Maria Bello; Francesca Galdiero; Anna Maria Trotta; Caterina Ieranò; Giuseppina Rea; Sabrina Chiara Cecere; Elisabetta Coppola; Salvatore Di Maro; Sandro Pignata; Daniela Califano; Stefania Scala

doi:10.1371/journal.pone.0314735

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Open Access

Peer-reviewed

Research Article

The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells

Daniela Russo ,

Contributed equally to this work with: Daniela Russo, Anna Spina

Roles Conceptualization, Data curation, Formal analysis, Software, Validation, Writing – original draft

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Anna Spina ,

Contributed equally to this work with: Daniela Russo, Anna Spina

Roles Conceptualization, Data curation, Formal analysis, Software, Validation, Writing – original draft

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Luigi Portella,

Roles Formal analysis, Funding acquisition, Software, Visualization

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Anna Maria Bello,

Roles Formal analysis, Visualization

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Francesca Galdiero,

Roles Formal analysis, Visualization

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Anna Maria Trotta,

Roles Formal analysis, Visualization

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Caterina Ieranò,

Roles Formal analysis, Visualization

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Giuseppina Rea,

Roles Formal analysis, Visualization

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Sabrina Chiara Cecere,

Roles Formal analysis, Visualization

Affiliation Uro-Gynecologic Oncology Unit, Istituto Nazionale Tumori IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Elisabetta Coppola,

Roles Formal analysis, Visualization

Affiliation Uro-Gynecologic Oncology Unit, Istituto Nazionale Tumori IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Salvatore Di Maro,

Roles Formal analysis, Visualization

Affiliation Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Caserta, Italy

https://orcid.org/0000-0002-9286-4433

⨯
Sandro Pignata,

Roles Formal analysis, Funding acquisition, Visualization

Affiliation Uro-Gynecologic Oncology Unit, Istituto Nazionale Tumori IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Daniela Califano,

Roles Formal analysis, Visualization

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯
Stefania Scala

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: s.scala@istitutotumori.na.it

Affiliation Microenvironment Molecular Targets, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", Naples, Italy
⨯

The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells

Daniela Russo,
Anna Spina,
Luigi Portella,
Anna Maria Bello,
Francesca Galdiero,
Anna Maria Trotta,
Caterina Ieranò,
Giuseppina Rea,
Sabrina Chiara Cecere,
Elisabetta Coppola

Published: December 19, 2024
https://doi.org/10.1371/journal.pone.0314735

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