Inhibition of CFTR-mediated intestinal chloride secretion by nornidulin: Cellular mechanisms and anti-secretory efficacy in human intestinal epithelial cells and human colonoids

• Chamnan Yibcharoenporn,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft

  Affiliation Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand

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• Thidarat Kongkaew,

  Roles Formal analysis, Investigation

  Affiliation Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand

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• Nichakorn Worakajit,

  Roles Formal analysis, Investigation

  Affiliations Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand, Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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• Rungtiwa Khumjiang,

  Roles Formal analysis, Investigation

  Affiliation Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand

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• Praphatsorn Saetang,

  Roles Investigation, Resources

  Affiliations Department of Science, Faculty of Science and Technology, Prince of Songkla University, Pattani, Thailand, Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand

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• Saravut Satitsri,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand

  https://orcid.org/0000-0002-1555-4917

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• Vatcharin Rukachaisirikul,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand

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• Chatchai Muanprasat

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: chatchai.mua@mahidol.ac.th

  Affiliation Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand

  https://orcid.org/0000-0001-6849-6637

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