The ameliorative effect of pioglitazone against colistin-induced nephrotoxicity is mediated by inhibition of NF-κB and restoration of Nrf2 signaling: An integrative bioinformatics prediction-guided in vitro study

• Metab Alharbi ,

  Contributed equally to this work with: Metab Alharbi, Mohamed A. Mahmoud

  Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: mesalharbi@ksu.edu.sa

  Affiliation Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

  https://orcid.org/0000-0001-8287-4470

  ⨯
• Mohamed A. Mahmoud ,

  Contributed equally to this work with: Metab Alharbi, Mohamed A. Mahmoud

  Roles Data curation, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

  https://orcid.org/0000-0001-5651-5618

  ⨯
• Abdulrahman Alshammari,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

  ⨯
• Mashal M. Almutairi,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

  ⨯
• Jihan M. Al-Ghamdi,

  Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia

  ⨯
• Jawza F. Alsabhan,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Clinical Pharmacy, College of pharmacy, King Saud University, Riyadh, Saudi Arabia

  ⨯
• Othman Al Shabanah,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

  ⨯
• Norah A. Alshalawi,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

  ⨯
• Sami I. Alzarea,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia

  https://orcid.org/0000-0003-4007-4023

  ⨯
• Abdullah F. Alasmari

  Roles Data curation, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliation Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

  ⨯