Comparison of a SARS-CoV-2 mRNA booster immunization containing additional antigens to a spike-based mRNA vaccine against Omicron BA.5 infection in hACE2 mice

• Jacklyn R. Hurst,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Biological Sciences Platform, Sunnybrook Research Institute at Sunnybrook Health Sciences Centre, Toronto, ON, Canada

  ⨯
• Maedeh Naghibosadat,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Biological Sciences Platform, Sunnybrook Research Institute at Sunnybrook Health Sciences Centre, Toronto, ON, Canada

  ⨯
• Patrick Budowski,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Institute of Medical Sciences, University of Toronto, Ontario, Canada

  ⨯
• Jun Liu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Providence Therapeutics Holdings, Inc., Calgary, AB, Canada

  ⨯
• Philip Samaan,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

  ⨯
• Frans Budiman,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Medicine, University of Toronto, Toronto, ON, Canada

  ⨯
• Alexandra Kurtesi,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada

  ⨯
• Fredo Qi,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada

  https://orcid.org/0000-0002-2859-3667

  ⨯
• Haritha Menon,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Providence Therapeutics Holdings, Inc., Calgary, AB, Canada

  ⨯
• Rajesh Krishnan,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Providence Therapeutics Holdings, Inc., Calgary, AB, Canada

  ⨯
• Jumai Abioye,

  Roles Methodology, Writing – review & editing

  Affiliation Providence Therapeutics Holdings, Inc., Calgary, AB, Canada

  ⨯
• Anne-Claude Gingras,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

  ⨯
• Mario Ostrowski,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Medicine, University of Toronto, Toronto, ON, Canada

  ⨯
• Natalia Martin Orozco,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Providence Therapeutics Holdings, Inc., Calgary, AB, Canada

  https://orcid.org/0000-0002-4033-3577

  ⨯
• Robert A. Kozak

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: rob.kozak@sunnybrook.ca

  Affiliations Biological Sciences Platform, Sunnybrook Research Institute at Sunnybrook Health Sciences Centre, Toronto, ON, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada, Division of Microbiology, Sunnybrook Health Sciences Centre, Department of Laboratory Medicine and Molecular Diagnostics, Toronto, ON, Canada

  https://orcid.org/0009-0006-1499-700X

  ⨯