MARCHF8-mediated ubiquitination via TGFBI regulates NF-κB dependent inflammatory responses and ECM degradation in intervertebral disc degeneration

Xingpeng Zhang; Guang Li; Fang Tan; Tao Yu; Chengping Xu; Kai Li; Feng Zhang; Meiyan Zhang; Jian Wang

doi:10.1371/journal.pone.0314021

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Open Access

Peer-reviewed

Research Article

MARCHF8-mediated ubiquitination via TGFBI regulates NF-κB dependent inflammatory responses and ECM degradation in intervertebral disc degeneration

Xingpeng Zhang ,

Contributed equally to this work with: Xingpeng Zhang, Guang Li

Roles Formal analysis

Affiliation Department of Orthopedics, Shanghai Pudong New Area People’s Hospital, Shanghai, China
⨯
Guang Li ,

Contributed equally to this work with: Xingpeng Zhang, Guang Li

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Department of Traumatic Surgery, Emergency Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
⨯
Fang Tan,

Roles Data curation, Formal analysis

Affiliation Department of Orthopedics, Shanghai Pudong New Area People’s Hospital, Shanghai, China
⨯
Tao Yu,

Roles Data curation

Affiliation Department of Orthopedics, Shanghai Pudong New Area People’s Hospital, Shanghai, China
⨯
Chengping Xu,

Roles Data curation

Affiliation Department of Orthopedics, Shanghai Pudong New Area People’s Hospital, Shanghai, China
⨯
Kai Li,

Roles Data curation

Affiliation Department of Orthopedics, Shanghai Pudong New Area People’s Hospital, Shanghai, China
⨯
Feng Zhang ,

Roles Writing – original draft

* E-mail: jianwangmd@aliyun.com (JW); zhangfeng@shpdph.com (FZ); angelmyhome@163.com (MZ)

Affiliation Department of Orthopedics, Shanghai Pudong New Area People’s Hospital, Shanghai, China
⨯
Meiyan Zhang ,

Roles Writing – original draft

* E-mail: jianwangmd@aliyun.com (JW); zhangfeng@shpdph.com (FZ); angelmyhome@163.com (MZ)

Affiliation Shanghai Circle Harmony Xinyong Clinic, Shanghai, China
⨯
Jian Wang

Roles Writing – review & editing

* E-mail: jianwangmd@aliyun.com (JW); zhangfeng@shpdph.com (FZ); angelmyhome@163.com (MZ)

Affiliation Department of Orthopedics, Shanghai Pudong New Area People’s Hospital, Shanghai, China

https://orcid.org/0009-0007-1268-113X

⨯

MARCHF8-mediated ubiquitination via TGFBI regulates NF-κB dependent inflammatory responses and ECM degradation in intervertebral disc degeneration

Xingpeng Zhang,
Guang Li,
Fang Tan,
Tao Yu,
Chengping Xu,
Kai Li,
Feng Zhang,
Meiyan Zhang,
Jian Wang

Published: January 3, 2025
https://doi.org/10.1371/journal.pone.0314021

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TGF-beta signaling cascade
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Extracellular matrix
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Protein expression
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