A novel family of beta mixture models for the differential analysis of DNA methylation data: An application to prostate cancer

Koyel Majumdar; Romina Silva; Antoinette Sabrina Perry; Ronald William Watson; Andrea Rau; Florence Jaffrezic; Thomas Brendan Murphy; Isobel Claire Gormley

doi:10.1371/journal.pone.0314014

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Open Access

Peer-reviewed

Research Article

A novel family of beta mixture models for the differential analysis of DNA methylation data: An application to prostate cancer

Koyel Majumdar,

Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Mathematics and Statistics, University College Dublin, Dublin, Ireland
⨯
Romina Silva,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliations School of Medicine, University College Dublin, Dublin, Ireland, Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin, Ireland
⨯
Antoinette Sabrina Perry,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliations Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin, Ireland, School of Biology and Environmental Science, University College Dublin, Dublin, Ireland
⨯
Ronald William Watson,

Roles Validation, Writing – review & editing

Affiliations School of Medicine, University College Dublin, Dublin, Ireland, Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin, Ireland
⨯
Andrea Rau,

Roles Methodology, Validation, Writing – review & editing

Affiliation INRAE, UMR1313 AgroParisTech, GABI, Université Paris-Saclay, Gif-sur-Yvette, France

https://orcid.org/0000-0001-6469-488X

⨯
Florence Jaffrezic,

Roles Methodology, Validation, Writing – review & editing

Affiliation INRAE, UMR1313 AgroParisTech, GABI, Université Paris-Saclay, Gif-sur-Yvette, France
⨯
Thomas Brendan Murphy,

Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Mathematics and Statistics, University College Dublin, Dublin, Ireland
⨯
Isobel Claire Gormley

Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: claire.gormley@ucd.ie

Affiliation School of Mathematics and Statistics, University College Dublin, Dublin, Ireland

https://orcid.org/0000-0001-7713-681X

⨯

A novel family of beta mixture models for the differential analysis of DNA methylation data: An application to prostate cancer

Koyel Majumdar,
Romina Silva,
Antoinette Sabrina Perry,
Ronald William Watson,
Andrea Rau,
Florence Jaffrezic,
Thomas Brendan Murphy,
Isobel Claire Gormley

Published: December 11, 2024
https://doi.org/10.1371/journal.pone.0314014

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DNA methylation
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Prostate cancer
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Methylation
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Benign tumors
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Treatment guidelines
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Simulation and modeling
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Cancers and neoplasms
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