Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study

• Summan Thahiem ,

  Contributed equally to this work with: Summan Thahiem, Muhammad Ihsan

  Roles Conceptualization, Investigation

  Affiliation Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

  ⨯
• Muhammad Ihsan ,

  Contributed equally to this work with: Summan Thahiem, Muhammad Ihsan

  Roles Conceptualization, Investigation

  Affiliation Department of Biosciences, COMSATS University Islamabad, Tarlai Kalan, Islamabad, Pakistan

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• Hamza Muneer,

  Roles Conceptualization, Formal analysis, Methodology

  Affiliations Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, Department of Biochemistry & Biotechnology, MNS University of Agriculture Multan, Multan, Pakistan

  https://orcid.org/0009-0001-1427-5545

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• Aamir Sohail,

  Roles Data curation, Methodology, Resources

  Affiliation Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

  ⨯
• Mehmand Khan,

  Roles Formal analysis, Resources, Validation

  Affiliation Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

  ⨯
• Iram Murtaza,

  Roles Data curation, Resources, Visualization

  Affiliation Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

  ⨯
• Zia Uddin,

  Roles Data curation, Methodology, Validation, Visualization

  Affiliation Department of Pharmacy, COMSATS University Islamabad, Abbottabad, KP, Pakistan

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• Muhammad Shafique ,

  Roles Conceptualization, Funding acquisition, Resources, Validation, Visualization

  * E-mail: mshafique@su.edu.sa (MS); hamidpcmd@yahoo.com (HA); imranullah@qau.edu.pk (IU)

  Affiliation Department of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia

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• Khalid J. Alzahrani,

  Roles Conceptualization, Funding acquisition, Validation, Writing – review & editing

  Affiliation Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia

  https://orcid.org/0000-0002-6688-0106

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• Hamid Ali ,

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft

  * E-mail: mshafique@su.edu.sa (MS); hamidpcmd@yahoo.com (HA); imranullah@qau.edu.pk (IU)

  Affiliation Department of Biosciences, COMSATS University Islamabad, Tarlai Kalan, Islamabad, Pakistan

  https://orcid.org/0000-0002-3851-3990

  ⨯
• Imran Ullah

  Roles Data curation, Investigation, Writing – original draft

  * E-mail: mshafique@su.edu.sa (MS); hamidpcmd@yahoo.com (HA); imranullah@qau.edu.pk (IU)

  Affiliation Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

  https://orcid.org/0000-0003-4259-2844

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