Role of vitamins in the pathogenesis and treatment of restless leg syndrome: A systematic review and meta-analysis

Xiao-Min Xu; Jiang-hai Ruan; Tao Tao; Shu-li Xiang; Ren-liang Meng; Xiu Chen

doi:10.1371/journal.pone.0313571

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Open Access

Peer-reviewed

Research Article

Role of vitamins in the pathogenesis and treatment of restless leg syndrome: A systematic review and meta-analysis

Xiao-Min Xu ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Writing – original draft

* E-mail: 706665270@qq.com (XC); xuxiaomin018167@163.com (XMX)

Affiliations Department of Neurology, The Affiliated Hospital of Southwest Medical University, Lu zhou, Sichuan, China, Laboratory of Neurological Diseases and Brain Function, Luzhou, Sichuan, China

https://orcid.org/0000-0002-3743-7981

⨯
Jiang-hai Ruan,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing

Affiliations Department of Neurology, The Affiliated Hospital of Southwest Medical University, Lu zhou, Sichuan, China, Laboratory of Neurological Diseases and Brain Function, Luzhou, Sichuan, China
⨯
Tao Tao,

Roles Data curation, Formal analysis, Methodology, Software, Writing – original draft

Affiliations Department of Neurology, The Affiliated Hospital of Southwest Medical University, Lu zhou, Sichuan, China, Laboratory of Neurological Diseases and Brain Function, Luzhou, Sichuan, China
⨯
Shu-li Xiang,

Roles Data curation, Methodology, Software

Affiliations Department of Neurology, The Affiliated Hospital of Southwest Medical University, Lu zhou, Sichuan, China, Laboratory of Neurological Diseases and Brain Function, Luzhou, Sichuan, China
⨯
Ren-liang Meng,

Roles Data curation, Methodology, Software

Affiliations Department of Neurology, The Affiliated Hospital of Southwest Medical University, Lu zhou, Sichuan, China, Laboratory of Neurological Diseases and Brain Function, Luzhou, Sichuan, China
⨯
Xiu Chen

Roles Conceptualization, Investigation, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: 706665270@qq.com (XC); xuxiaomin018167@163.com (XMX)

Affiliations Department of Neurology, The Affiliated Hospital of Southwest Medical University, Lu zhou, Sichuan, China, Laboratory of Neurological Diseases and Brain Function, Luzhou, Sichuan, China
⨯

Role of vitamins in the pathogenesis and treatment of restless leg syndrome: A systematic review and meta-analysis

Xiao-Min Xu,
Jiang-hai Ruan,
Tao Tao,
Shu-li Xiang,
Ren-liang Meng,
Xiu Chen

Published: March 10, 2025
https://doi.org/10.1371/journal.pone.0313571

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