Screening of serum biomarkers in patients with PCOS through lipid omics and ensemble machine learning

Ji-ying Chen; Wu-jie Chen; Zhi-ying Zhu; Shi Xu; Li-lan Huang; Wen-qing Tan; Yong-gang Zhang; Yan-li Zhao

doi:10.1371/journal.pone.0313494

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Open Access

Peer-reviewed

Research Article

Screening of serum biomarkers in patients with PCOS through lipid omics and ensemble machine learning

Ji-ying Chen ,

Roles Conceptualization, Data curation, Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: dr.chenjiying@hotmail.com

Affiliation Department of Obstetrics and Gynecology, Shenzhen Longhua District Central Hospital, Shenzhen, China

https://orcid.org/0000-0002-0487-2004

⨯
Wu-jie Chen,

Roles Conceptualization, Data curation, Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Obstetrics and Gynecology, Shenzhen Longhua District Central Hospital, Shenzhen, China
⨯
Zhi-ying Zhu,

Roles Conceptualization, Data curation, Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Obstetrics and Gynecology, Shenzhen Longhua District Central Hospital, Shenzhen, China
⨯
Shi Xu,

Roles Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, China
⨯
Li-lan Huang,

Roles Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of General Practice, Shenzhen Longhua District Central Hospital, Shenzhen, China
⨯
Wen-qing Tan,

Roles Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of General Practice, Shenzhen Longhua District Central Hospital, Shenzhen, China
⨯
Yong-gang Zhang,

Roles Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Clinical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, China
⨯
Yan-li Zhao

Roles Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Shenzhen, China
⨯

Screening of serum biomarkers in patients with PCOS through lipid omics and ensemble machine learning

Ji-ying Chen,
Wu-jie Chen,
Zhi-ying Zhu,
Shi Xu,
Li-lan Huang,
Wen-qing Tan,
Yong-gang Zhang,
Yan-li Zhao

Published: January 7, 2025
https://doi.org/10.1371/journal.pone.0313494

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Biomarkers
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Lipid metabolism
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Metabolites
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Polycystic ovary syndrome
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Machine learning
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Lipids
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Lipid analysis
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