Biweekly CAPOX versus triweekly CAPOX in the adjuvant therapy of post-surgery CRC: A randomized controlled trial

Hangyu Zhang; Danyang Wang; Zhou Tong; Tao Xiang; Xudong Zhu; Lulu Liu; Yi Zheng; Peng Zhao; Weijia Fang; Wenbin Chen

doi:10.1371/journal.pone.0313472

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Open Access

Peer-reviewed

Research Article

Biweekly CAPOX versus triweekly CAPOX in the adjuvant therapy of post-surgery CRC: A randomized controlled trial

Hangyu Zhang ,

Contributed equally to this work with: Hangyu Zhang, Danyang Wang

Roles Conceptualization, Writing – original draft

Affiliation Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China

https://orcid.org/0000-0003-1325-3915

⨯
Danyang Wang ,

Contributed equally to this work with: Hangyu Zhang, Danyang Wang

Roles Conceptualization

Affiliation Department of colorectal surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯
Zhou Tong,

Roles Data curation, Formal analysis

Affiliation Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯
Tao Xiang,

Roles Data curation, Formal analysis

Affiliation Department of colorectal surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯
Xudong Zhu,

Roles Data curation, Formal analysis

Affiliation Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯
Lulu Liu,

Roles Data curation, Formal analysis

Affiliation Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯
Yi Zheng,

Roles Supervision

Affiliation Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯
Peng Zhao,

Roles Supervision

Affiliation Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯
Weijia Fang,

Roles Supervision

Affiliation Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯
Wenbin Chen

Roles Writing – review & editing

* E-mail: wenbinchen@zju.edu.cn

Affiliation Department of colorectal surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯

Biweekly CAPOX versus triweekly CAPOX in the adjuvant therapy of post-surgery CRC: A randomized controlled trial

Hangyu Zhang,
Danyang Wang,
Zhou Tong,
Tao Xiang,
Xudong Zhu,
Lulu Liu,
Yi Zheng,
Peng Zhao,
Weijia Fang,
Wenbin Chen

Published: July 11, 2025
https://doi.org/10.1371/journal.pone.0313472

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