RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy

Hongmei Qian; Wei Chen; Guomei Yuan; Man Luo; Li Zhang; Biao Wu; Hanshi Huang; Jiahao Xu; Qiong Wang; Mengyun Li

doi:10.1371/journal.pone.0313446

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Open Access

Peer-reviewed

Research Article

RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy

Hongmei Qian ,

Contributed equally to this work with: Hongmei Qian, Wei Chen, Guomei Yuan

Roles Funding acquisition, Resources, Writing – original draft

Affiliation Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
⨯
Wei Chen ,

Contributed equally to this work with: Hongmei Qian, Wei Chen, Guomei Yuan

Roles Methodology, Supervision

Affiliation Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
⨯
Guomei Yuan ,

Contributed equally to this work with: Hongmei Qian, Wei Chen, Guomei Yuan

Roles Data curation, Formal analysis

Affiliation Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
⨯
Man Luo,

Roles Methodology, Project administration, Validation, Writing – review & editing

Affiliation Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
⨯
Li Zhang,

Roles Conceptualization, Data curation, Validation

Affiliation Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
⨯
Biao Wu,

Roles Funding acquisition, Methodology, Software

Affiliation Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
⨯
Hanshi Huang,

Roles Data curation, Resources

Affiliation Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
⨯
Jiahao Xu,

Roles Investigation

Affiliation Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
⨯
Qiong Wang ,

Roles Funding acquisition, Writing – original draft

* E-mail: limengyun1026@163.com (ML); 57164096@qq.com (QW)

Affiliation Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China

https://orcid.org/0009-0006-2295-7577

⨯
Mengyun Li

Roles Data curation, Funding acquisition, Writing – original draft

* E-mail: limengyun1026@163.com (ML); 57164096@qq.com (QW)

Affiliation Medical Research Center, Shaoxing People’s Hospital, Shaoxing, Zhejiang, China
⨯

RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy

Hongmei Qian,
Wei Chen,
Guomei Yuan,
Man Luo,
Li Zhang,
Biao Wu,
Hanshi Huang,
Jiahao Xu,
Qiong Wang,
Mengyun Li

Published: November 11, 2024
https://doi.org/10.1371/journal.pone.0313446

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Retinal ganglion cells
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Autophagic cell death
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Glaucoma
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Intraocular pressure
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Apoptosis
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Mouse models
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Retina
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Oxidative stress
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