Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement

Kyle D. Anderson; Bryan Dulion; John Wong; Niyati Patel; Anne DeBenedetti; Craig J. Della Valle; Ryan D. Ross

doi:10.1371/journal.pone.0312985

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Open Access

Peer-reviewed

Research Article

Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement

Kyle D. Anderson,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, Illinois, United States of America

https://orcid.org/0000-0002-5312-7801

⨯
Bryan Dulion,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
John Wong,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Niyati Patel,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Anne DeBenedetti,

Roles Data curation, Methodology, Project administration, Writing – review & editing

Affiliation Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Craig J. Della Valle,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Ryan D. Ross

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Ryan_ross@rush.edu

Affiliations Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, Illinois, United States of America, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America, Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, United States of America

https://orcid.org/0000-0003-3760-234X

⨯

Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement

Kyle D. Anderson,
Bryan Dulion,
John Wong,
Niyati Patel,
Anne DeBenedetti,
Craig J. Della Valle,
Ryan D. Ross

Published: May 15, 2025
https://doi.org/10.1371/journal.pone.0312985

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Surgical and invasive medical procedures
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Joint replacement surgery
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Alleles
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Single nucleotide polymorphisms
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Medical implants
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Inflammation
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